Immunological mechanisms responsible for radiation-induced abscopal effect

ME Rodríguez-Ruiz, C Vanpouille-Box, I Melero… - … in immunology, 2018 - cell.com
… that were progressing during immune checkpoint blockade, … Here, we review the
immunological mechanisms that are … tumor rejection and, in some cases, result in systemic effects. …

The immune mechanisms of abscopal effect in radiation therapy

GD Grass, N Krishna, S Kim - Current problems in cancer, 2016 - Elsevier
… to systematically evaluate the intricacies of the host immune system, the new generation of
… current biologic mechanisms thought to regulate the RT-induced abscopal effect and how …

Immune mechanisms mediating abscopal effects in radioimmunotherapy

ME Rodriguez-Ruiz, I Rodriguez, O Leaman… - Pharmacology & …, 2019 - Elsevier
… would potentiate the systemic beneficial effect of radiotherapy. Here, we review the
immunological mechanisms that are responsible for radiation-induced abscopal effects. …

Abscopal effect of radiotherapy combined with immune checkpoint inhibitors

Y Liu, Y Dong, L Kong, F Shi, H Zhu, J Yu - Journal of hematology & …, 2018 - Springer
… Nevertheless, the exact underlying mechanism of the abscopal effect remains unclear. In
general, we speculate that the immune mechanism of RT is responsible for, or at least …

The abscopal effect 67 years later: from a side story to center stage

S Demaria, SC Formenti - The British Journal of Radiology, 2020 - academic.oup.com
… Here, we will review the history and mechanisms of the abscopal effect of radiation and …
It also provided unequivocal evidence that the abscopal effect of radiation is immune-mediated, …

Abscopal effect in radioimmunotherapy

M Ashrafizadeh, B Farhood, AE Musa, S Taeb… - International …, 2020 - Elsevier
… the duration of immune system’s activity within tumor microenvironment (TME). In this review,
we explain the cellular and molecular mechanisms behind abscopal effect by radiotherapy …

Using immunotherapy to boost the abscopal effect

W Ngwa, OC Irabor, JD Schoenfeld, J Hesser… - Nature Reviews …, 2018 - nature.com
Abscopal response mechanism. Although the biological mechanism underlying the abscopal
effect is … Immune-mediated abscopal effects are also likely to be affected by such factors as …

Radiotherapy-mediated immunomodulation and anti-tumor abscopal effect combining immune checkpoint blockade

X Zhao, C Shao - Cancers, 2020 - mdpi.com
… However, the detailed mechanism of the abscopal effect induced by combined therapy is
still unclear. Therefore, how to formulate a therapeutic schedule to maximize the efficacy …

The abscopal effect in the era of checkpoint inhibitors

O Kodet, K Němejcova, K Strnadová… - International Journal of …, 2021 - mdpi.com
abscopal effect (Figure 1) and its immunological and molecular mechanisms in the context
of current immune … In this light, we demonstrate clinically the abscopal effect observed at our …

The controversial abscopal effect

JM Kaminski, E Shinohara, JB Summers… - Cancer treatment …, 2005 - Elsevier
… Elucidating the mechanisms of the abscopal effect could enable the development of effective
benign … These findings support the role of the immune system in the abscopal effect. The …