… efficiently engineered with a predetermined antigen-specificity via transfection of viral vectors
encoding specific T cell receptors (TCRs) or chimeric antigen receptors (CARs). Compared …

… Here, we use a modular system based on a chimeric antigen receptor (CAR) that binds …
Thus, transient genetic modification to produce mAbCAR T cells led to durable immune …

… antigens, data from preclinical models show that donor-reactive Tregs are more effective than
polyclonal Tregs in promoting transplant tolerance … receptors or chimeric antigen receptors …

… In this review, we introduce the concept of using CAR T cells to break immunological tolerance
to tumors, highlight several challenges in the field, discuss the utility of biomarkers in the …

… trials regarding cancer immunotherapy with chimeric antigen receptor (CAR)-engineered T
… patients to better tackle the issue of immunological tolerance. Adoptive immunotherapy (AIT) …

… With that, CAR Treg are providing hope in establishing allospecific, localized immune
tolerance in the long term‚ and the first clinical trials administering CAR Treg for the treatment of …

The engineering of T lymphocytes to express chimeric antigen receptors (CARs) aims to
establish T cell-mediated tumor immunity rapidly. In this study, we conducted a pilot clinical trial …

… Finally, through the prism of endogenous T-cell tonic signaling and its important regulatory
role in immune tolerance and cell-mediated adaptive immunity, we posit a number of …

… An advantage of cell-based immunotherapy is the ability to overcome immune tolerance and
generate immune memory. Advances in gene transfer technologies have led to the strategy …

… through the introduction of a chimeric antigen receptor (CAR) allows for generation of
tumor‐targeted T cells. Once expressed by T cells, CARs combine antigen‐specificity with T cell …