Considering immunomodulatory therapies in the septic patient: should apoptosis be a potential therapeutic target?

A Oberholzer, C Oberholzer, RM Minter, LL Moldawer - Immunology Letters, 2001 - Elsevier
… part to technical difficulties associated with their administration and tissue targeting, inhibition
of lymphocyte apoptosis may be an appropriate therapeutic target for the septic patient. …

Interferon-λs: special immunomodulatory agents and potential therapeutic targets

Y Zheng, H Li, J Yu, H Zhao, SE Wang… - Journal of Innate …, 2013 - karger.com
… This review summarizes the current understanding of the immunomodulatory activities of
IFN- s … These latest studies suggest that IFN- s will be a potential therapeutic target in clinical …

Immunomodulation—a general review of the current state-of-the-art and new therapeutic strategies for targeting the immune system

M Strzelec, J Detka, P Mieszczak… - Frontiers in …, 2023 - frontiersin.org
therapeutic targets and the development of effective methods for the selective introduction
of RNA molecules into particular cells and organs in order to prevent its off-target activity. …

[HTML][HTML] Immunomodulation of interleukin-34 and its potential significance as a disease biomarker and therapeutic target

Y Ge, M Huang, Y Yao - International Journal of Biological …, 2019 - ncbi.nlm.nih.gov
… Therefore, IL-34 may be interesting as a novel marker to monitor IBD severity, and as a
potential therapeutic target for treatment of the inflamed gut. In addition to the significance of IL-…

Therapeutic potential of HDPs as immunomodulatory agents

H Jenssen, REW Hancock - Antimicrobial Peptides: Methods and …, 2010 - Springer
… will discuss the potential therapeutic use of HDPs and IDRs as immunomodulatory agents. …
based on innate immunity should employ tailored immunomodulators that offer the potential

Mesenchymal stem cell immunomodulation: mechanisms and therapeutic potential

N Song, M Scholtemeijer, K Shah - Trends in pharmacological sciences, 2020 - cell.com
immunomodulatory potential, in which regulatory T cells and monocytes play a key role. We
review the immunomodulatory … the potential of successfully using MSCs in clinical settings. …

Is JAK3 a new drug target for immunomodulation-based therapies?

AC Papageorgiou, LEK Wikman - Trends in pharmacological sciences, 2004 - cell.com
… Compared with other members of the JAK family, JAK3 has attracted much attention as a
potential drug target. This is based on two facts. First, JAK3 is found primarily in hematopoietic …

Thalidomide derived immunomodulatory drugs (IMiDs) as potential therapeutic agents

JB Marriott, K Dredge… - Current Drug Targets …, 2003 - ingentaconnect.com
… cytokines and adhesion molecules it represents a therapeutic target; TNF blockade has since
been validated as a therapeutic treatment in various inflammatory diseases [29]. Therefore, …

Inflammation and Wnt signaling: target for immunomodulatory therapy?

I Jridi, K Canté-Barrett, K Pike-Overzet… - Frontiers in cell and …, 2021 - frontiersin.org
… These data suggest that Wnt signaling may play an important role in regulating inflammation
and might be an interesting therapeutic target to control inflammation. In this review, we …

Pharmaco-immunomodulatory therapy in COVID-19

JG Rizk, K Kalantar-Zadeh, MR Mehra, CJ Lavie… - Drugs, 2020 - Springer
… It is also approved for the management of chimeric antigen receptor (CAR) T-cell-induced
CRS [24], making it a possible therapeutic option for CRS of severely ill COVID-19 patients …