Immunomodulatory therapies in sepsis

WJ Kox, T Volk, SN Kox, HD Volk - Intensive care medicine, 2000 - Springer
septic patients, targeted intervention may lead to more success in immunomodulation of
sepsis… detected in serum and body fluids of septic patients [4], although the complex network …

Immunomodulatory therapy for sepsis: an update

E Christaki, P Anyfanti, SM Opal - … review of anti-infective therapy, 2011 - Taylor & Francis
… and the underlying pathophysiological pathways of sepsis. The development of intensive …
therapy and surgical techniques have improved the overall medical care of the septic patient. …

Why immunomodulatory therapies have not worked in sepsis

E Abraham - Intensive care medicine, 1999 - search.proquest.com
… A number of immunomodulatory therapies aimed at decreasing the dysregulated
inflammatory response have been examined in patients with sepsis (Table 1). Despite initially …

New perspectives on immunomodulatory therapy for bacteraemia and sepsis

SM Opal - International Journal of Antimicrobial Agents, 2010 - Elsevier
… in septic patients during … immunomodulatory agents in sepsis will necessitate a personalised
medicine approach to treat each patient at the appropriate time and with the optimal therapy

Considering immunomodulatory therapies in the septic patient: should apoptosis be a potential therapeutic target?

A Oberholzer, C Oberholzer, RM Minter, LL Moldawer - Immunology Letters, 2001 - Elsevier
… anti-apoptotic therapies for septic patients at present, further exploration of this clinical
approach is clearly warranted. The successful treatment of the patient with sepsis will require …

Immunomodulation in critically ill septic patients

GA Hassan, MA Azkol, SM Helal… - Menoufia Medical …, 2015 - menoufia-med-j.com
… of immunomodulatory therapies as well as current therapies trialed previously and potential
therapies … This study enrolled 64 patients with severe sepsis or septic shock who underwent …

The new normal: immunomodulatory agents against sepsis immune suppression

NA Hutchins, J Unsinger, RS Hotchkiss… - Trends in molecular …, 2014 - cell.com
… The diminished capacity of septic patients to fight and eliminate infections often leads to the
development of secondary infections, mediated by otherwise weakly virulent or opportunistic …

Changes in immune function and immunomodulatory treatments of septic patients

Z Xu, A Liu, L Yang, B Zhang, F Zheng, J Zhang… - Clinical …, 2022 - Elsevier
… function of septic patients and some promising therapies for sepsis are summarized in this
review. Firstly, the innate immune system would be over-activated at the early stage of sepsis. …

Immunomodulatory therapies for sepsis: unexpected effects with macrolides

EJ Giamarellos-Bourboulis - International journal of antimicrobial agents, 2008 - Elsevier
… reduced to 3.78 among clarithromycin-treated patients. These results render new perspectives
for the future application of clarithromycin as an immunomodulatory therapy of sepsis. …

Cytokines, sepsis and immunomodulation

RG Molloy, JA Mannick, ML Rodrick - British Journal of Surgery, 1993 - Wiley Online Library
… also reported a close correlation between the detection of TNF in the serum of patients
suffering from shock (septic and non-septic) and the risk of developing adult respiratory distress …