[HTML][HTML] Can immunostimulatory agents enhance the abscopal effect of radiotherapy?

A Levy, C Chargari, A Marabelle, JL Perfettini… - European Journal of …, 2016 - Elsevier
abscopal effect. We review here the preclinical and clinical evidence for the abscopal effect
and highlight the therapeutic prospects of combining RT with immune-modulating agents, …

The systemic immunostimulatory effects of radiation therapy producing overall tumor control through the abscopal effect

MA D'Andrea, GK Reddy - Journal of Radiation Oncology, 2019 - Springer
… Alterations in the microenvironment then prompt reactivation of the immune response, a
phenomenon called an abscopal effect of radiation therapy. The abscopal effect of radiation was …

[HTML][HTML] Radiotherapy-mediated immunomodulation and anti-tumor abscopal effect combining immune checkpoint blockade

X Zhao, C Shao - Cancers, 2020 - mdpi.com
… can baffle the anti-tumor immunity and abscopal effects stimulated by local RT to promote the
survival … There is a balance between immunosuppression and immunostimulation. Without …

Abscopal effect in radioimmunotherapy

M Ashrafizadeh, B Farhood, AE Musa, S Taeb… - International …, 2020 - Elsevier
… For this aim, it is important to induce abscopal effect in primary … is the best choice for inducing
abscopal effect. On the other hand… mechanisms behind abscopal effect by radiotherapy and …

Using immunotherapy to boost the abscopal effect

W Ngwa, OC Irabor, JD Schoenfeld, J Hesser… - Nature Reviews …, 2018 - nature.com
… the abscopal effect (from 'ab scopus', that is, away from the target). The abscopal effect
has … However, the effect is rare because at the time of treatment, established immune-tolerance …

[HTML][HTML] Immunostimulatory effects of radiotherapy for local and systemic control of melanoma: A review

J Takahashi, S Nagasawa - International journal of molecular sciences, 2020 - mdpi.com
… We also investigated the mechanism underlying the abscopal effect, case studies on the
abscopal effect, and the candidate biomarkers used in those published case studies. …

Abscopal effects of radiotherapy are enhanced by combined immunostimulatory mAbs and are dependent on CD8 T cells and crosspriming

ME Rodriguez-Ruiz, I Rodriguez, S Garasa, B Barbes… - Cancer research, 2016 - AACR
Abscopal effects of radiotherapy are synergized by anti-CD137 and anti-PD1 … a model to
monitor the abscopal effects of radiotherapy in combination with immunostimulatory mAbs. Eight …

Immune mechanisms mediating abscopal effects in radioimmunotherapy

ME Rodriguez-Ruiz, I Rodriguez, O Leaman… - Pharmacology & …, 2019 - Elsevier
… but also against distant non-irradiated metastases (abscopal effects). A series of clinical
trials are exploring the beneficial effects of radioimmunotherapy combinations. The concepts of …

[HTML][HTML] The abscopal effect: a review of pre-clinical and clinical advances

JR Janopaul-Naylor, Y Shen, DC Qian… - International journal of …, 2021 - mdpi.com
… In this review, we summarize pre-clinical and clinical reports, with a specific focus on the
mechanisms behind the immunostimulatory effects of radiation and how this is enhanced by …

Brachytherapy attains abscopal effects when combined with immunostimulatory monoclonal antibodies

ME Rodriguez-Ruiz, I Rodriguez, B Barbes, L Mayorga… - Brachytherapy, 2017 - Elsevier
… The goal of this work is to study the abscopal effects of radiotherapy instigated by … and when
used in combination in an attempt to produce abscopal effects. To study the abscopal effects