[HTML][HTML] Can immunostimulatory agents enhance the abscopal effect of radiotherapy?
A Levy, C Chargari, A Marabelle, JL Perfettini… - European Journal of …, 2016 - Elsevier
… abscopal effect. We review here the preclinical and clinical evidence for the abscopal effect
and highlight the therapeutic prospects of combining RT with immune-modulating agents, …
and highlight the therapeutic prospects of combining RT with immune-modulating agents, …
The systemic immunostimulatory effects of radiation therapy producing overall tumor control through the abscopal effect
MA D'Andrea, GK Reddy - Journal of Radiation Oncology, 2019 - Springer
… Alterations in the microenvironment then prompt reactivation of the immune response, a
phenomenon called an abscopal effect of radiation therapy. The abscopal effect of radiation was …
phenomenon called an abscopal effect of radiation therapy. The abscopal effect of radiation was …
[HTML][HTML] Radiotherapy-mediated immunomodulation and anti-tumor abscopal effect combining immune checkpoint blockade
X Zhao, C Shao - Cancers, 2020 - mdpi.com
… can baffle the anti-tumor immunity and abscopal effects stimulated by local RT to promote the
survival … There is a balance between immunosuppression and immunostimulation. Without …
survival … There is a balance between immunosuppression and immunostimulation. Without …
Abscopal effect in radioimmunotherapy
… For this aim, it is important to induce abscopal effect in primary … is the best choice for inducing
abscopal effect. On the other hand… mechanisms behind abscopal effect by radiotherapy and …
abscopal effect. On the other hand… mechanisms behind abscopal effect by radiotherapy and …
Using immunotherapy to boost the abscopal effect
… the abscopal effect (from 'ab scopus', that is, away from the target). The abscopal effect
has … However, the effect is rare because at the time of treatment, established immune-tolerance …
has … However, the effect is rare because at the time of treatment, established immune-tolerance …
[HTML][HTML] Immunostimulatory effects of radiotherapy for local and systemic control of melanoma: A review
J Takahashi, S Nagasawa - International journal of molecular sciences, 2020 - mdpi.com
… We also investigated the mechanism underlying the abscopal effect, case studies on the
abscopal effect, and the candidate biomarkers used in those published case studies. …
abscopal effect, and the candidate biomarkers used in those published case studies. …
Abscopal effects of radiotherapy are enhanced by combined immunostimulatory mAbs and are dependent on CD8 T cells and crosspriming
ME Rodriguez-Ruiz, I Rodriguez, S Garasa, B Barbes… - Cancer research, 2016 - AACR
… Abscopal effects of radiotherapy are synergized by anti-CD137 and anti-PD1 … a model to
monitor the abscopal effects of radiotherapy in combination with immunostimulatory mAbs. Eight …
monitor the abscopal effects of radiotherapy in combination with immunostimulatory mAbs. Eight …
Immune mechanisms mediating abscopal effects in radioimmunotherapy
ME Rodriguez-Ruiz, I Rodriguez, O Leaman… - Pharmacology & …, 2019 - Elsevier
… but also against distant non-irradiated metastases (abscopal effects). A series of clinical
trials are exploring the beneficial effects of radioimmunotherapy combinations. The concepts of …
trials are exploring the beneficial effects of radioimmunotherapy combinations. The concepts of …
[HTML][HTML] The abscopal effect: a review of pre-clinical and clinical advances
… In this review, we summarize pre-clinical and clinical reports, with a specific focus on the
mechanisms behind the immunostimulatory effects of radiation and how this is enhanced by …
mechanisms behind the immunostimulatory effects of radiation and how this is enhanced by …
Brachytherapy attains abscopal effects when combined with immunostimulatory monoclonal antibodies
ME Rodriguez-Ruiz, I Rodriguez, B Barbes, L Mayorga… - Brachytherapy, 2017 - Elsevier
… The goal of this work is to study the abscopal effects of radiotherapy instigated by … and when
used in combination in an attempt to produce abscopal effects. To study the abscopal effects …
used in combination in an attempt to produce abscopal effects. To study the abscopal effects …
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