Immunotherapy of colon cancer

A Stein, G Folprecht - Oncology research and treatment, 2018 - karger.com
responses in the refractory setting by PD-1/-L1 +/- CTLA 4 inhibition. Thus, ongoing phase 3
trials in this subgroup evaluate immunotherapyimmunotherapeutic agents (eg CEA-TCB). …

Predictors of response to immunotherapy in colorectal cancer

J González-Montero, CI Rojas, M Burotto - The Oncologist, 2024 - academic.oup.com
… -stage colon cancer. The … response to immunotherapy. Concurrently, the NICHE-2 study,21
conducted as a follow-up, encompassed 112 patients diagnosed with dMMR colon cancer. …

Predictive biomarkers of colon cancer immunotherapy: Present and future

W Hou, C Yi, H Zhu - Frontiers in immunology, 2022 - frontiersin.org
… However, the independent application of TMB for the prediction of immunotherapy
response in colon cancer is still controversial. In the KEYNOTE 177 trial, the limits of TMB as a …

Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers

M Chalabi, LF Fanchi, KK Dijkstra, JG Van den Berg… - Nature medicine, 2020 - nature.com
… of neoadjuvant immunotherapy compared … response to neoadjuvant chemotherapy in dMMR
tumors in the FOXTROT study, and the 100% response rate to neoadjuvant immunotherapy

… society for immunotherapy of cancer study of the consensus immunoscore for the prediction of survival and response to chemotherapy in stage III colon cancer

B Mlecnik, C Bifulco, G Bindea, F Marliot… - Journal of clinical …, 2020 - ascopubs.org
PURPOSE The purpose of this study was to evaluate the prognostic value of Immunoscore
in patients with stage III colon cancer (CC) and to analyze its association with the effect of …

Current immunotherapeutic strategies in colon cancer

M Morse, L Langer, A Starodub, A Hobeika… - … Oncology Clinics of …, 2007 - Elsevier
… and adaptive immune response within colorectal cancer supports the … colon cancer also
result in the expression of numerous mutant epitopes that may be targets of immune responses […

Cancer-related serological recognition of human colon cancer: identification of potential diagnostic and immunotherapeutic targets

MJ Scanlan, S Welt, CM Gordon, YT Chen, AO Gure… - Cancer research, 2002 - AACR
… been used to evaluate the serological response of 74 colon cancer patients and 75 normal
… a colon cancer-related serological response and altered mRNA expression in colon cancer. …

Prognostic and predictive value of BGN in colon cancer outcomes and response to immunotherapy

ZX He, SB Zhao, X Fang, JF E, HY Fu, YH Song… - Frontiers in …, 2022 - frontiersin.org
… immune response was analyzed. Finally, we predicted the immunotherapeutic response rates
… BGN expression presented a better immunotherapeutic response in colon cancer patients. …

APC mutation correlated with poor response of immunotherapy in colon cancer

B Li, G Zhang, X Xu - BMC gastroenterology, 2023 - Springer
colon cancer tumorigenesis. However, the connection between APC gene mutation and
immunotherapy efficacy for colon cancer … mutation on immunotherapy efficacy for colon cancer. …

Active specific immunotherapy for stage II and stage III human colon cancer: a randomised trial

JB Vermorken, AME Claessen, H Van Tinteren, HE Gall… - The Lancet, 1999 - thelancet.com
… Our efforts have focused on active specific immunotherapy (ASI) that makes use of the patient's
tumour to elicit a long-term cell-mediated immune response as adjuvant therapy. Clinical …