Impaired expression of GABA transporters in the human Alzheimer's disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus
TE Fuhrer, TH Palpagama, HJ Waldvogel, BJL Synek… - Neuroscience, 2017 - Elsevier
… in the expression of the GATs in the Alzheimer’s disease (AD) hippocampus, entorhinal
cortex and superior temporal gyrus. We found a significant increase in BGT-1 expression …
cortex and superior temporal gyrus. We found a significant increase in BGT-1 expression …
Expression level of vascular endothelial growth factor in hippocampus is associated with cognitive impairment in patients with Alzheimer's disease
H Tang, XO Mao, L Xie, DA Greenberg, K Jin - Neurobiology of aging, 2013 - Elsevier
… In the current study, we examined the VEGF expression levels in the hippocampus of patients
with … increased VEGF expression in the neurons and astrocytes in the hippocampus and …
with … increased VEGF expression in the neurons and astrocytes in the hippocampus and …
Targeting hippocampal adult neurogenesis using transcription factors to reduce Alzheimer's disease‐associated memory impairments
… to hippocampal-dependent learning and memory. This has led to the hypothesis that
memory impairments associated with neurodegenerative diseases such as Alzheimer's disease …
memory impairments associated with neurodegenerative diseases such as Alzheimer's disease …
Glucocorticoid hypersecretion and the age-impaired hippocampus: cause or effect?
JR Seckl, T Olsson - Journal of endocrinology, 1995 - joe.bioscientifica.com
… In Alzheimer's disease, hippocampal GR and MR gene expression are maintained at control
levels in surviving neurones, despite a generalised loss of neuronal gene expression and …
levels in surviving neurones, despite a generalised loss of neuronal gene expression and …
Neuronal and glial alterations, increased anxiety, and cognitive impairment before hippocampal amyloid deposition in PDAPP mice, model of Alzheimer's disease
J Beauquis, A Vinuesa, C Pomilio, P Pavía… - …, 2014 - Wiley Online Library
… disease. In the present work we describe early astroglial, synaptic, and neuronal changes in
the hippocampus … beta amyloid peptides and minimal hippocampal amyloid deposition are …
the hippocampus … beta amyloid peptides and minimal hippocampal amyloid deposition are …
Hippocampus development and function: role of epigenetic factors and implications for cognitive disease
PS Lagali, CP Corcoran, DJ Picketts - Clinical genetics, 2010 - Wiley Online Library
… Therefore, a knowledge of how epigenetic events orchestrate hippocampal neuron and …
for therapeutic intervention in cases of neurological disease involving cognitive impairment. …
for therapeutic intervention in cases of neurological disease involving cognitive impairment. …
Synaptic gene dysregulation within hippocampal CA1 pyramidal neurons in mild cognitive impairment
SE Counts, MJ Alldred, S Che, SD Ginsberg… - …, 2014 - Elsevier
… selective vulnerability of hippocampal CA1 pyramidal … impairment during the early phases
of Alzheimer's disease (AD). Disruption of this neuronal population likely affects hippocampal …
of Alzheimer's disease (AD). Disruption of this neuronal population likely affects hippocampal …
Hippocampus and human disease
M Walker, D Chan, M Thom - 2006 - discovery.ucl.ac.uk
… cortex, the damage in the earliest stages of disease is restricted to the entorhinal cortex
and the hippocampus, and the memory impairment that results from this disruption of the …
and the hippocampus, and the memory impairment that results from this disruption of the …
Hippocampus and its involvement in Alzheimer's disease: a review
… the hippocampus shows … hippocampal regions are the structural markers in magnetic
resonance imaging (MRI). Lack of sirtuin (SIRT) expression in the hippocampal neurons will impair …
resonance imaging (MRI). Lack of sirtuin (SIRT) expression in the hippocampal neurons will impair …
The hippocampus in aging and disease: from plasticity to vulnerability
T Bartsch, P Wulff - Neuroscience, 2015 - Elsevier
… Impairment of hippocampal neurogenesis may thus contribute to cognitive deficits seen in
depression. Besides the putative role in pattern separation, adult neurogenesis is also thought …
depression. Besides the putative role in pattern separation, adult neurogenesis is also thought …
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