… production in response to low-dose LPS; however, our finding of altered NF-κB activation …
LPS indicates that maximal activation of the NF-κB signal transduction pathway in the lungs …

… Pathophysiologically, it can be assumed that impaired control mechanisms of IKK/NF-κB
activation result in a dysbalance of inflammatory and immune responses because of increased …

… In light of data implicating NF-κB activation in inflammatory processes, we first tested whether
the IκBα(ΔN) transgene leads to any impaired type 1 T cell-dependent response by using …

… NF-κB-dependent gene, in response to TNFα … response is completely ablated in the ζPKC
−/− EFs. Therefore, it seems that, at least in fibroblasts, ζPKC appears to be essential for the κB-…

… Both the Th1 response to T. gondii and the capacity to produce specific high … impaired in
bcl-3 knockout mice. Moreover, consistent with the failure to mount a normal antibody response, …

… , indicating that NF-κB1 and, by association, classical NF-κB are not … impaired immune
response (50). Expression of some genes thought to require NF-κB was not affected in the NF-κB1-…

… genes that control the immune response that NF-κB is of most … NF-κB regulates gene
transcription by binding to κB sites in … B cells, indicating a critical impairment in B cell development. …

… B cell proliferation was significantly impaired in response to LPS, anti-δ-dextran, or CD40
ligand. The phenotype of p100/p52 −/− mice was similar to that of a Bcl-3 knockout (see below)…

… LPS-stimulated neuroinflammation and memory impairment through maintaining cellular
oxidative balance and blocking the NF-κB transcriptional pathway, illustrating that the …

… of the p50 subunit of NF-κB in models of acute and persistent nociception using NF-κB p50
−/− mice. We found that these mice showed impaired basal responses to mechanical as well …