… 6, which displays a partial Ag presentation defect and expresses a mutated DM β-chain
with Cys79 replaced by Tyr. In this study, we show that HLA-DR molecules in 7.12. 6 have a …

… HLA-DO–HLA-DM complex shows that it blocks HLA-DM activity as a substrate mimic. Alterations
in the efficiency of DM… The assembly of DO heterodimers is inefficient in the absence of …

… may be linked to genetic variations in HLA-DM genes. Future studies should focus on
clarifying the implications of DM natural variations under physiologically relevant conditions. …

… II molecule HLA-DM. Cell biological and biochemical characterization of HLA-DM provided
deeper insight into the molecular mechanisms underlying the loading process: HLA-DM …

… Is not Located on the Cell Surface We were unable to determine whether HLA-DM is surface
expressed by FACS analysis, since RDMB-C was generated to the cytoplasmic domain of …

… The implication of these findings is that disturbances of DM … HLA-DM is present in one-fifth
the amount of HLA.DR in the class II … with leupeptin-induced peptide (LIP)-HLA-DR complexes …

… MHC class II synthesis and assembly with chaperones 4. Biochemical and structural … In
this review, we discuss our current understanding of HLA-DM function in peptide exchange and …

… The exchange of HLA class II–associated invariant chain peptides (CLIP) for cognate peptide
is catalyzed by HLA-DM under acidic conditions in vitro by an unknown mechanism. Here, …

… HLA-DM function. We determined the X-ray crystal structure of HLA-DO bound to HLA-DM
and … In the crystal structure, the DO and DM molecules bind in a side-by-side arrangement …

… Thus, DR1βH81N might represent a 'post-DM effect' conformation. We suggest that DM
may mediate peptide dissociation by a 'hit-and-run' mechanism that results in conformational …