Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease

JP Segain, DR De La Blétiere, A Bourreille, V Leray… - Gut, 2000 - gut.bmj.com
… key factors in the pathogenesis of Crohn's disease (CD). … patients. As butyrate enemas may
be beneficial in treating colonic inflammation, we investigated if butyrate promotes this effect

Defective acute inflammation in Crohn's disease: a clinical investigation

DJB Marks, MWN Harbord, R MacAllister, FZ Rahman… - The Lancet, 2006 - thelancet.com
reaction and produce a secondary chronic inflammation. We undertook to examine acute
inflammatory responses in Crohn's disease … , we investigated the consequences of trauma to …

Bacteria in Crohn's disease: mechanisms of inflammation and therapeutic implications

RB Sartor - Journal of clinical gastroenterology, 2007 - journals.lww.com
… Transient infection with pathogenic organisms could serve as environmental triggers to
initiate inflammatory responses that are perpetuated in susceptible hosts by commensal …

Crohn's disease: an immune deficiency state

DJB Marks, FZ Rahman, GW Sewell… - Clinical reviews in allergy & …, 2010 - Springer
… the downstream consequences of chronic inflammation. The … -infectious inflammatory bowel
disease arising in patients with … the innate inflammatory response in Crohn’s disease in the …

Crohn's disease

F Shanahan - The Lancet, 2002 - thelancet.com
… forms of inflammatory bowel disease, with an adverse effect on … In Crohn's disease, mucosal
T cells are resistant to apoptosis… of T cells and perpetuation of the inflammatory response. …

Managing immunogenic responses to infliximab: treatment implications for patients with Crohn's disease

PD Han, RD Cohen - Drugs, 2004 - Springer
… In an analysis of 129 patients treated with infliximab for … Crohn’s disease, we described
infusion reactions as complicating 5–13% of infusions.[10] In 100 patients with Crohn’s disease, …

[HTML][HTML] Nutritional modulation of the inflammatory response in inflammatory bowel disease-from the molecular to the integrative to the clinical

GE Wild, L Drozdowski, C Tartaglia… - World journal of …, 2007 - ncbi.nlm.nih.gov
… provide important supportive therapy for IBD patients, but in adults … of IBD patients, and
recent studies have stressed the role of PPAR on NFκB activity on the potential beneficial effect of …

[HTML][HTML] Current view of the immunopathogenesis in inflammatory bowel disease and its implications for therapy

MI Torres, A Rios - World journal of gastroenterology: WJG, 2008 - ncbi.nlm.nih.gov
… antigen presentation, with maintenance of intestinal immuno-regulation and tolerance to
components of intestinal flora, controlling the inflammatory responses to intestinal antigens[26]. …

Modulation of inflammation by autophagy: consequences for Crohn's disease

TS Plantinga, LAB Joosten, JWM van der Meer… - Current opinion in …, 2012 - Elsevier
… A major effect of autophagy in inflammation is modulation of the production of the … inflammatory
responses, but also reshape our insights into the pathogenesis of inflammatory diseases. …

The immune response in inflammatory bowel disease

SJ Brown, L Mayer - Official journal of the American College of …, 2007 - journals.lww.com
IBD. In some individuals, the overt inflammatory response may be an appropriate response
… are important considerations. A combination of oral plus topical therapy may also maximize …