The molecular pathogenesis of prostate cancer: implications for prostate cancer prevention

WG Nelson, AM De Marzo, TL DeWeese - Urology, 2001 - Elsevier
Prostate cancer has become 1 of the most commonly diagnosed cancers in the United …
tissues obtained at autopsy indicate that the development of life-threatening prostate cancer in the …

Anatomy of the prostate revisited: implications for prostate biopsy and zonal origins of prostate cancer

SW Fine, VE Reuter - Histopathology, 2012 - Wiley Online Library
… In summary, this review provides a modern update of our understanding of prostatic
anatomy and its clinical implications for identifying and classifying prostatic tumours. We have …

A comprehensive review of the role of zinc in normal prostate function and metabolism; and its implications in prostate cancer

LC Costello, RB Franklin - Archives of biochemistry and biophysics, 2016 - Elsevier
… The implications of zinc in the development and progression of prostate cancer are described,
which is the most consistent hallmark characteristic of prostate cancer. The requirement …

The molecular biology of prostate cancer: current understanding and clinical implications

J Gandhi, A Afridi, S Vatsia, G Joshi, G Joshi… - … cancer and prostatic …, 2018 - nature.com
… polymorphisms recurrent throughout the prostate cancer-diagnosed genome. Castration-resistant
prostate cancer is the most aggressive form of prostate cancer, and its research has …

Obesity, serum prostate specific antigen and prostate size: implications for prostate cancer detection

SJ Freedland, EA Platz, JC Presti Jr, WJ Aronson… - The Journal of …, 2006 - Elsevier
… Given that pathological prostate cancer volumes were not recorded in our … cancer as a
surrogate of prostate cancer volume. To exclude the possibility that men with large prostate cancer

Novel role of zinc in the regulation of prostate citrate metabolism and its implications in prostate cancer

LC Costello, RB Franklin - The Prostate, 1998 - Wiley Online Library
… Most importantly, in prostate cancer (Pca) the capability for net citrate production is lost.
In addition to citrate, the normal and BPH (benign prostatic hyperplasia) prostate also …

[HTML][HTML] Cellular and molecular mechanisms underlying prostate cancer development: therapeutic implications

U Testa, G Castelli, E Pelosi - Medicines, 2019 - mdpi.com
… two main molecular groups of prostate cancers: one characterized by the … implication of
field effects may have potentially important implications for the understanding of prostate cancer

The genetic epidemiology of prostate cancer and its clinical implications

R Eeles, C Goh, E Castro, E Bancroft, M Guy… - Nature reviews …, 2014 - nature.com
… with prostate cancer risk, which … of prostate cancer aetiology and would enable population
risk stratification for screening. Furthermore, understanding the genetic risks of prostate cancer

[HTML][HTML] New genomic structure for prostate cancer specific gene PCA3 within BMCC1: implications for prostate cancer detection and progression

RA Clarke, Z Zhao, AY Guo, K Roper, L Teng, ZM Fang… - PloS one, 2009 - journals.plos.org
Background The prostate cancer antigen 3 (PCA3/DD3) gene is a highly specific biomarker
upregulated in prostate cancer (PCa). In order to understand the importance of PCA3 in PCa …

Acquisition of neuroendocrine characteristics by prostate tumor cells is reversible: implications for prostate cancer progression

ME Cox, PD Deeble, S Lakhani, SJ Parsons - Cancer research, 1999 - AACR
… These findings have important implications for our understanding of the apparently complex
network of events that eventually leads to androgen-independent growth of prostate tumors …