Cloning and transgenesis in mammals: Implications for xenotransplantation

JA Piedrahita, B Mir - American Journal of Transplantation, 2004 - Wiley Online Library
… In xenotransplantation, the species of choice remains the pig … that are suitable for
xenotransplantation, complex genetic mod… advances in transgenic manipulation and cloning in …

Recent advances in understanding xenotransplantation: implications for the clinic

DKC Cooper, R Bottino - Expert review of clinical immunology, 2015 - Taylor & Francis
… islet xenotransplantation (using a GTKO pig transgenic for the … months after porcine
islet xenotransplantation into the portal … cloned pigs. Proc Natl Acad Sci USA 2013;110(12):4557-62 …

Debates in xenotransplantation: on the consequences of contradiction

N Brown - New Genetics and Society, 1999 - Taylor & Francis
… Institute's cloning expertise to the development of transgenic porcine donors. … , transgenic
porcine tissues also trigger anitbodies made by B cells. Suppressing two major aspects of the …

Current and future prospects for xenotransplantation

AJ French, JL Greenstein, BE Loveland… - Reproduction, Fertility …, 1998 - CSIRO Publishing
Transgenic pigs required for xenotransplantation will soon be generated at a greater efficiency
and precision using nuclear transfer and cloning … now focus on issues and approaches …

Risk of pathogenic virus transmission by somatic cell nuclear transfer: implications for xenotransplantation

J Denner - Biology of Reproduction, 2022 - academic.oup.com
… for the generation of cloned and transgenic animals bears the risk … significance is this topic
in the case of xenotransplantation … genetically modified pigs designed for xenotransplantation. …

Porcine PD‐L1: cloning, characterization, and implications during xenotransplantation

DH Jeon, K Oh, BC Oh, DH Nam, CH Kim… - …, 2007 - Wiley Online Library
Transgenic transfer of protective human complement regulatory genes, such as human …
increase the clinical feasibility of xenotransplantation and long-term disease-free status [1]. …

Xenotransplantation: the next generation of engineered animals

AJF d'Apice, PJ Cowan - Transplant immunology, 2009 - Elsevier
Transgenesis and cloning were giant enabling technological … these technologies serve
xenotransplantation even better. … The consequences of knocking out genes and of transgenic

The possibilities of practical application of transgenic mammalian species generated by somatic cell cloning in pharmacology, veterinary medicine and …

M Samiec, M Skrzyszowska - Polish Journal of Veterinary Sciences, 2011 - agro.icm.edu.pl
… Donors of grafts for pig-to-human -xenotransplantation Animal models of human monogenic
… silencing of PRNP locus has very important implications for veterinary medicine and animal …

Xenotransplantation-progress and problems: a review

J Denner - 2014 - edoc.rki.de
… Last not least, xenotransplantation may be associated with … ethical aspects of
xenotransplantation had been taken place. … the possibility to produce cloned and transgenic pigs …

Application of reproductive biotechnology in animals: implications and potentials: applications of reproductive cloning

L Paterson, P DeSousa, W Ritchie, T King… - Animal reproduction …, 2003 - Elsevier
cloning of adult transgenic livestock has the potential for the production of great quantities of
therapeutic proteins. Transgenic cloned … assessment before xenotransplantation proceeds. …