… and free radicals in mitochondria. Recently, we have demonstrated that the copy number
of mitochondrial DNA (mtDNA) is increased in the lung tissues of elderly human subjects. The …

… One chemotherapeutic strategy utilizes delocalized lipophilic cations (DLCs) that accumulate
selectively in carcinoma cells in response to increased mitochondrial membrane potential. …

… breast cancer MCF-7 cells to doxorubicin, Abraxane, and carboplatin. In conclusion, the …
mitochondria into human breast cancer cells inhibits cancer cell proliferation and increases the …

… Once considered exclusively the cell's powerhouse, mitochondria are now recognized to …
in contrast with the expectation that increasing mitochondrial dysfunction would cause a linear …

… directly the mitochondrial activity of the mitochondrial-transformed cells and found that
following mitochondrial … causing an increase in both cell viability and direct mitochondrial-activity. …

… increased ROS production in the human cell during replicative senescence results in an
increase in mitochondrial … causes an even higher level of ROS production in the senescent cells. …

… mass and mtDNA content were concurrently increased … increase of mitochondrial mass
and mtDNA are the molecular events associated with enhanced oxidative stress in human cells …

… in mitochondrial respiration and reactive oxygen species production in primary human …
induces a decrease in mitochondrial mass and an increase in membrane potential (ΔΨm) …

… N-acetylcysteine restores cell growth and reverses the increase in senescence-associated
β-… by increasing mitochondrial number via retroviral-mediated expression of the mitochondrial …

… to stain mitochondria of the human cell line HL-60, we have followed their increase over the
cell … A near-linear synthesis of mitochondrial mass was shown to occur over the cell cycle. A …