PP2A inactivation is a crucial step in triggering apoptin-induced tumor-selective cell killing

R Zimmerman, DJ Peng, H Lanz, YH Zhang… - Cell death & …, 2012 - nature.com
… within the PP2A-binding site on the activation of apoptin by (… Activation of tumor-selective
apoptosis-inducing proteins is … the B56δ subunit of PP2A leading to increased PP2A activity. …

The PP2A-associated protein α4 is an essential inhibitor of apoptosis

M Kong, CJ Fox, J Mu, L Solt, A Xu, RM Cinalli… - Science, 2004 - science.org
… However, no changes in the expression or activation status of the Jun kinases were detected…
in caspase-3 activation (fig. S4). As in proliferating cells, increased phosphorylation of p53 …

Apoptosis induced by protein phosphatase 2A (PP2A) inhibition in T leukemia cells is negatively regulated by PP2A-associated p38 mitogen-activated protein kinase

RTM Boudreau, DM Conrad, DW Hoskin - Cellular signalling, 2007 - Elsevier
… In addition, PP2A activation of ERK downstream of signaling … Fas-mediated apoptosis [16].
However, the precise role of … in increased apoptosis, suggesting that p38 MAPK activation in …

The role and therapeutic potential of Ser/Thr phosphatase PP2A in apoptotic signalling networks in human cancer cells

V Janssens, A Rebollo - Current molecular medicine, 2012 - ingentaconnect.com
… of PP2A activated by a proapoptotic stimulus, such as ceramide [45]. Bcl-XL is a major anti-…
mechanism involves a direct increase of PP2A activity because 1/ PP2A inhibitors, such as …

[HTML][HTML] Phosphatases in apoptosis: to be or not to be, PP2A is in the heart of the question

C Van Hoof, J Goris - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2003 - Elsevier
PP2A activates pro-apoptotic and inhibits anti-apoptotic … that PP2A has a positive regulatory
function in apoptosis. … an increase in PP2A activity towards specific pro-apoptotic substrates …

PP2A regulates the pro-apoptotic activity of FOXO1

L Yan, VA Lavin, LR Moser, Q Cui, C Kanies… - Journal of Biological …, 2008 - ASBMB
PP2A inhibitors, okadaic acid and fostriecin, increased … binds to FOXO1, and PP2A catalytic
subunit was identified in … inhibitors was the result of activation of upstream kinases, we …

PKR negatively regulates leukemia progression in association with PP2A activation, Bcl-2 inhibition and increased apoptosis

X Cheng, RL Bennett, X Liu, M Byrne… - Blood Cancer …, 2013 - nature.com
PP2A activation may be necessary for the full and potent initiation of apoptosis, we investigated
whether direct activation of PP2A … For these studies, the specific PP2A activator FTY720 …

Activation of a PP2A-like phosphatase and dephosphorylation of τ protein characterize onset of the execution phase of apoptosis

JC Mills, VMY Lee, RN Pittman - Journal of cell science, 1998 - journals.biologists.com
apoptosis which is consistent with activation of PP2A phosphatase being a common feature
of the execution phase of apoptosis. … MT disassembly contributes to increased PP2A activity. …

High-glucose-induced apoptosis, ROS production and pro-inflammatory response in cardiomyocytes is attenuated by metformin treatment via PP2A activation

G Cheng, L Li - Journal of biosciences, 2020 - Springer
… We confirmed that metformin treatment would significantly increase PP2A activity by …
Our data clearly showed that PP2A activity participated in the anti-apoptotic and anti-inflammatory …

A novel PP2A enhancer induces caspase-independent apoptosis of MKN28 gastric cancer cells with high MEK activity

A Tsuchiya, T Kanno, T Shimizu, S Nakao, A Tanaka… - Cancer Letters, 2014 - Elsevier
… cells with highly activated MEK by enhancing PP2A activity and dephosphorylating MEK. …
due to apoptosis, we performed TUNEL staining. diDCP-LA-PI (100 μM) significantly increased