… function. In this review, we consider structural changes which occur in OA that are linked with
… odds of mild pain (vs no pain) and had a marked increased risk of moderate to severe knee …

… In an MMT animal model, increased functional connectivity was observed 3–5 weeks post
MMT in … Whether this increased functional connectivity during OA contributes to chronic pain …

… Results We demonstrate increased TRPV1 immunoreactivity … In a model of OA pain,
we report increased joint levels of 12-… of joint afferents and inhibited pain behaviour (weight-bearing …

… increasing in many countries, mostly related to age and obesity, leading to an increased
number of people having OA pain, … or lead to reduced pain, stiffness or functional loss. Vitamin D …

… [26] , a simple exercise program resulted in increased quadriceps strength and joint position
sense, reduced pain, and improved function as judged by timed activities. Finally, Maurer et …

… Joint pain is the hallmark symptom of osteoarthritis (OA) and … OA pain greatly contributes
to functional limitations of joints … Increased central sensitization is also associated with pain at …

… , compared with placebo, in relieving pain and increasing function in people with OA. Their
dose–response curve seems to be reasonably flat with regard to pain relief, such that only …

… Increased TrkA receptor signaling in MIA-induced OA in transgenic mice harboring a TrkA
gain-of-function mutation resulted in increased pain accompanied by higher numbers of …

… increase (gain of function) or decrease (loss of function) in sensitivity of the nociceptive system
and to evaluate the status of specific pain … i) the mechanisms involved in joint pain, ii) how …

… to nociceptors that can either increase or reduce pain 30 . Nociceptors in turn can release
neuropeptides and neurotransmitters that, for example, modulate the function of innate and …