… with increased mortality rates attributed to hemorrhagic death.3, 4, 5 Tranexamic acid (TXA)
is an antifibrinolytic medication that was associated with a reduction in mortality after trauma …

… as tranexamic acid, inhibit blood clot breakdown (fibrinolysis) and can reduce perioperative
bleeding. Tranexamic acid has … To assess the effects of tranexamic acid on mortality, blood …

… resulted in increased mortality (… increased mortality. We found that an estimated lysis at 30
minutes (LY-30) of 3.0% to be an inflection point at which the rate of mortality greatly increased…

… The CRASH-2 trial showed that a short course of tranexamic acid given within … mortality
with no apparent increase in the risk of adverse thrombotic events.As a result, tranexamic acid is …

… We found 4 articles demonstrating an overall mortality benefit in trauma patients who were
treated with tranexamic acid. We recommend early treatment with tranexamic acid in trauma …

… low or intermediate risk and that the mortality reduction from tranexamic acid does not vary
by baseline risk. We found no evidence of any increase in vascular occlusive events in any of …

… Only sensitivity analysis of observational studies after exclusion of studies with high risk of
bias from confounders revealed that tranexamic acid is associated with an increased risk for …

… at a dose of 100 mg/kg was significantly associated with seizure in one randomised controlled
trial [5]; however, tranexamic acid did not increase seizure when it was used at a dose of 2 …

… tranexamic acid to reduce morbidity and mortality in surgical and traumatic bleeding. Tranexamic
acid has been shown to reduce mortality … that there is no increased efficacy in using a …

… increased risk of renal toxicity of aprotinin when compared with TXA with a potential increase
in mortality… be associated with increased mortality compared with a control, TXA and ε-ACA. …