Molecular mechanisms responsible for increased vulnerability of the ageing oocyte to oxidative damage

BP Mihalas, KA Redgrove… - Oxidative medicine …, 2017 - Wiley Online Library
… of oxidative damage in the maternally aged oocyte likely results from the convergence of an
increase in … capacity of the oocyte to mitigate oxidative damage. We also urge further basic …

Selective vulnerability to kainate‐induced oxidative damage in different rat brain regions

E Candelario‐Jalil, SM Al‐Dalain… - Journal of Applied …, 2001 - Wiley Online Library
… Our goal in this study was to determine the pattern of oxidative damage induced by
systemically administered KA in selected areas of the rat brain at two different sampling times. …

Pathways of oxidative damage

JA Imlay - Annual Reviews in Microbiology, 2003 - annualreviews.org
… Conversely, the vulnerability ofbacteria to DNA damage is increased by mutations that
upregulate iron importand thereby elevate intracellular iron levels(88). The iron that catalyzes …

Selective neuronal vulnerability to oxidative stress in the brain

X Wang, EK Michaelis - Frontiers in aging neuroscience, 2010 - frontiersin.org
… of some neurons is partially underlied by deficient DNA damage repair. As described earlier…
in a region that is vulnerable to OS, the repair of DNA damage was increased initially but did …

Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia

SE Browne, AC Bowling, U Macgarvey… - Annals of Neurology …, 1997 - Wiley Online Library
… of energetic defects and oxidative damage in the disease … evidence of impaired oxidative
phosphorylation enzyme activities … We also measured levels of the oxidative damage product 8-…

[HTML][HTML] Increasing vulnerability of astrocytes to oxidative injury with age despite constant antioxidant defenses

MC Papadopoulos, IL Koumenis, TY Yuan, RG Giffard - Neuroscience, 1997 - Elsevier
… reflects oxidative damage since it is significantly reduced by either trolox or dimethylthiourea,
and may, in common with the other injury paradigms, in part reflect the increased oxidative

Oligodendroglia are particularly vulnerable to oxidative damage after neurotrauma in vivo

MK Giacci, CA Bartlett, NM Smith, KS Iyer… - Journal of …, 2018 - Soc Neuroscience
vulnerable to this damage remain to be elucidated. Here we use powerful NanoSIMS techniques
to show increased oxidative damage … are the most vulnerable to DNA oxidation. Further …

Increase in vulnerability to oxidative damage in cholesterol-modified erythrocytes exposed to t-BuOOH

A López-Revuelta, JI Sánchez-Gallego… - … et Biophysica Acta (BBA …, 2005 - Elsevier
… and membrane susceptibility to oxidative damage induced by … increased ROS production,
with almost complete oxidation of … Fluorescence anisotropy studies showed an increase in the …

How important is oxidative damage? Lessons from Alzheimer's disease

G Perry, AK Raina, A Nunomura, T Wataya… - Free Radical Biology …, 2000 - Elsevier
… Therefore, increases in oxidative damage do not necessitate … to oxidative stress given that
the cell may have increased its … increased flux of reactive oxygen responsible for the damage. …

MPP+ increases the vulnerability to oxidative stress rather than directly mediating oxidative damage in human neuroblastoma cells

HS Lee, CW Park, YS Kim - Experimental Neurology, 2000 - Elsevier
… no increase in lipid peroxidation, a sign of oxidative damage. Our results indicate that MPP at
neurotoxic concentrations did not provoke oxidative damage… to assess oxidative damage to …