The effect of UGT1A9, CYP2B6 and CYP2C9 genes polymorphism on individual differences in propofol pharmacokinetics among Polish patients undergoing …

A Mikstacki, O Zakerska-Banaszak… - … of Applied Genetics, 2017 - Springer
… of genetic changes c.516G>T in the CYP2B6, c.98T>C in the UGT1A9 and c.1075A>C in
the CYP2C9 genes on the individual … We have genotyped CYP2B6, UGT1A9 and CYP2C9

Clinical relevance of genetic polymorphisms in the human CYP2C9 gene

UI Schwarz - European journal of clinical investigation, 2003 - Wiley Online Library
… Single-nucleotide polymorphisms (SNP) in the CYP2C9 gene have increasingly been … that
underlies interindividual and ethnic differences. Apart from the wild-type protein CYP2C9*1 at …

Pharmacogenomics signature: A novel strategy on the individual differences in drug response

C Guo, X Lin, J Yin, X Xie, J Li, X Meng, J Wu, L Huang… - Cancer letters, 2018 - Elsevier
… and CYP2C9 genetic polymorphisms … individual variations in drug responses [25]. This
study provides further conception that, rather than individual or several foci, a large set of genetic

Genetic analysis of the human cytochrome P450 CYP2C9 locus

MJ Stubbins, LW Harries, G Smith… - Pharmacogenetics …, 1996 - journals.lww.com
… The genetic analysis of CYP2C9 carried out in this study does not rule out the possibility
that other CYP2C9 alleles exist. The size of the study could be enlarged in an effort to detect …

The impact of CYP2C9 genetics and oral contraceptives on cytochrome P450 2C9 phenotype

M Sandberg, I Johansson, M Christensen… - Drug metabolism and …, 2004 - ASPET
CYP2C9 gene expression might explain these differences. Therefore, until a genetic explanation
for these individual differences … the individual CYP2C9 activity using specific CYP2C9

Prediction of the Effects of Genetic Polymorphism on the Pharmacokinetics of CYP2C9 Substrates from In Vitro Data

M Kusama, K Maeda, K Chiba, A Aoyama… - Pharmaceutical …, 2009 - Springer
… The *2 and *3 alleles of CYP2C9, with decreased enzymatic activity, are highly polymorphic
and contribute to inter-individual differences in pharmacotherapy of CYP2C9 substrates. …

Impact of genetic polymorphisms in CYP2C9 and CYP2C19 on the pharmacokinetics of clinically used drugs

T Hirota, S Eguchi, I Ieiri - Drug metabolism and pharmacokinetics, 2013 - jstage.jst.go.jp
… The frequency of non-functional alleles in the CYP2C9 gene is relatively low.However, these
… report is to review the clinical impact of variants of the CYP2C9 and 2C19 genes. CYP2C9

Interethnic and Intraethnic Variability of CYP2C8 and CYP2C9 Polymorphisms in Healthy Individuals

E García-Martín, C Martínez, JM Ladero… - Molecular diagnosis & …, 2006 - Springer
… Several variant alleles have been described for both CYP2C8 and CYP2C9 genes, although
so far data on human variability in the allele frequencies are limited. Besides the variant …

Pharmacogenomics of CYP2C9: Functional and Clinical Considerations

AK Daly, AE Rettie, DM Fowler, JO Miners - Journal of personalized …, 2017 - mdpi.com
… Polymorphisms resulting in decreased enzyme activity are common in the CYP2C9 gene
and this, combined with narrow therapeutic indices for several key drug substrates, results in …

The pharmacogenetics of CYP2C9 and CYP2C19: ethnic variation and clinical significance

J Rosemary, C Adithan - Current clinical pharmacology, 2007 - ingentaconnect.com
… The genes encoding CYP2C9 and CYP2C19 are polymorphically expressed [… individual
differences in drug metabolism. Many global populations have been genotyped for the CYP2C9