[HTML][HTML] Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets

R Qin, FM You, Q Zhao, X Xie, C Peng, G Zhan… - Journal of hematology & …, 2022 - Springer
… olaparib) to exhibit therapeutic potential against various cancers … death by indole alkaloids
against different targets is expected to … the development of new strategies for cancer therapy. …

[HTML][HTML] Indole-based small molecules as potential therapeutic agents for the treatment of fibrosis

R Qin, Q Zhao, B Han, HP Zhu, C Peng… - Frontiers in …, 2022 - frontiersin.org
… the potential of natural indole alkaloids, semi-synthetic indole alkaloids, synthetic indole
derivatives, and indole-… is to verify the therapeutic effects and activities of indole alkaloids and its …

Therapeutic potential of indole alkaloids in respiratory diseases: A comprehensive review

S Mitra, SR Prova, SA Sultana, R Das, F Nainu… - Phytomedicine, 2021 - Elsevier
… This review also discusses clinical studies exploring the therapeutic efficacy of indole
alkaloids, which have confirmed the promising benefits observed in vivo and in vitro. …

[HTML][HTML] Advances in indole-containing alkaloids as potential anticancer agents by regulating autophagy

ML Luo, W Huang, HP Zhu, C Peng, Q Zhao… - Biomedicine & …, 2022 - Elsevier
indole alkaloids' effect on tumor cells and autophagy. Then, we focus on mechanisms by
which indole alkaloids can target … The study about IADB may support novel therapeutic targets

[HTML][HTML] The therapeutic prospects of naturally occurring and synthetic indole alkaloids for depression and anxiety disorders

S Munir, A Shahid, B Aslam, UA Ashfaq… - Evidence-Based …, 2020 - hindawi.com
… However, studies on the antidepressant potential of indole alkaloids from plants or … the
potential of indole alkaloids from plants and of marine origin as well as synthetic indole alkaloids

[HTML][HTML] Research progress of indole alkaloids: targeting MAP kinase signaling pathways in cancer treatment

M Al Amin, TB Emran, J Khan, M Zehravi, I Sharma… - Cancers, 2023 - mdpi.com
indole alkaloids affect the MAPK signaling pathway in cancer treatment and focus on
advancements in the role of indole alkaloidsindole alkaloids to achieve the desired therapeutic

Alkaloids for cancer prevention and therapy: Current progress and future perspectives

A Mondal, A Gandhi, C Fimognari, AG Atanasov… - European journal of …, 2019 - Elsevier
… Fascaplysin, an indole alkaloid isolated from marine sponge, … Fourteen indole alkaloids
were extracted from the stem and … Indole alkaloids coronaridine, voacangine and heyneanine …

[HTML][HTML] Update of Indoles: Promising molecules for ameliorating metabolic diseases

W Hu, G Yan, Q Ding, J Cai, Z Zhang, Z Zhao… - Biomedicine & …, 2022 - Elsevier
… Among all kinds of alkaloids, indole alkaloids, related to the … Indole alkaloids are generally
extracted from the plant … As pharmacologically active secondary metabolites, indole alkaloids

[HTML][HTML] Ajmalicine and reserpine: Indole alkaloids as multi-target directed ligands towards factors implicated in Alzheimer's disease

P Kashyap, V Kalaiselvan, R Kumar, S Kumar - Molecules, 2020 - mdpi.com
… in the current study, are indole alkaloids; reserpine (RES) and … -target drug ligand potential
of reserpine and ajmalicine. The selected compounds demonstrated to bind with AD targets

Marine indole alkaloids: potential new drug leads for the control of depression and anxiety

AJ Kochanowska-Karamyan, MT Hamann - Chemical reviews, 2010 - ACS Publications
… In this review, we have discussed 46 natural indole alkaloids of marine origin and 87
synthetic molecules. The synthesis of monoindole alkaloids was in many cases inspired by the …