[HTML][HTML] Update of Indoles: Promising molecules for ameliorating metabolic diseases

W Hu, G Yan, Q Ding, J Cai, Z Zhang, Z Zhao… - Biomedicine & …, 2022 - Elsevier
… Among all kinds of alkaloids, indole alkaloids, related to the … Indole alkaloids are generally
extracted from the plant … As pharmacologically active secondary metabolites, indole alkaloids

Research progress of indole compounds with potential antidiabetic activity

Y Zhu, J Zhao, L Luo, Y Gao, H Bao, P Li… - European Journal of …, 2021 - Elsevier
indole alkaloids to screen their antidiabetic activities. In this present review, we focus on indole
alkaloids … Recently, PPARα and PPARγ had been identified to be the therapeutic targets

Indole alkaloids from marine resources: Understandings from therapeutic point of view to treat cancers

F Islam, Z Dehbia, M Zehravi, R Das… - Chemico-Biological …, 2023 - Elsevier
… It is significant to highlight that thorough SAR investigations help to optimize the biological
activities of these marine indole alkaloids for possible therapeutic applications by offering …

An insight in anti-malarial potential of indole scaffold: A review

M Chauhan, A Saxena, B Saha - European journal of medicinal chemistry, 2021 - Elsevier
… This enzyme can be inhibited by Apicidin which is an indole alkaloid [5]. Malaria along with
being widely prevalent has become a grave problem due to the evolution of drug resistant …

[HTML][HTML] Marine-derived indole alkaloids and their biological and pharmacological activities

JT Wibowo, P Ahmadi, SI Rahmawati, A Bayu… - Marine Drugs, 2021 - mdpi.com
… This review reports the indole alkaloids isolated during the … indole alkaloids reported from
2016 to 2021 were collected from various scientific databases. A total of 186 indole alkaloids

Potential therapeutic applications of plant‐derived alkaloids against inflammatory and neurodegenerative diseases

B Aryal, BK Raut, S Bhattarai… - Evidence‐Based …, 2022 - Wiley Online Library
possible therapeutic targets to suppress the inflammatory pathogenesis of diseases. Figure
3 illustrates the mechanism of alkaloids … Among monoterpene indole alkaloids extracted from …

[HTML][HTML] Anti-Alphaviral Alkaloids: Focus on Some Isoquinolines, Indoles and Quinolizidines

AL Sandenon Seteyen, E Girard-Valenciennes… - Molecules, 2022 - mdpi.com
potential in multifactorial chronic health conditions including immunological, metabolic and
neurologic disorders [55]. Indole alkaloids … predominant monoterpene indole alkaloids which …

Indole and indoline scaffolds in drug discovery

F Liu, M Su - Privileged Scaffolds in Drug Discovery, 2023 - Elsevier
… Nortopsentins A–C (Nortopsentins D) (4) as indole alkaloids were isolated from Spongosorites
ruetzleri and showed in vitro cytotoxicity against P388 lymphocytic leukemia cells (IC 50 , …

Current Status of Indole-Derived Marine Natural Products: Synthetic Approaches and Therapeutic Applications

S Fernández, V Arnáiz, D Rufo, Y Arroyo - Marine Drugs, 2024 - mdpi.com
… and functional versatility of indole alkaloid derivatives spots them as … potential applications
in drug discovery. Therefore, the purpose of this review is to exclusively cover indole alkaloid

Indoleamine and tryptophan 2, 3-dioxygenases as important future therapeutic targets

A Dolšak, S Gobec, M Sova - Pharmacology & Therapeutics, 2021 - Elsevier
… , IDOs and TDO represent important targets for therapeutic intervention. This pathway has
… This review summarizes recent advances on IDO and TDO as potential drug targets, and …