Harnessing the chemistry of the indole heterocycle to drive discoveries in biology and medicine

VM Norwood IV, RW Huigens III - ChemBioChem, 2019 - Wiley Online Library
… by molecular interactions between indole agent and critical therapeutic target. The chemical
… compounds of clinical use, complex indole alkaloids and indole-inspired discovery efforts …

[HTML][HTML] Protein kinases as therapeutic targets to develop anticancer drugs with natural alkaloids

H Ye, L Wang, L Ma, M Ionov, G Qiao… - Frontiers in Bioscience …, 2021 - imrpress.com
… 2), an indole alkaloid and isolated from Melodinus suaveolens, showed potent anticancer
effect against human promyelocytic leukemia HL-60, human liver cancer SMMC-7721, human …

Chemical and biological perspectives of monoterpene indole alkaloids from Rauwolfia species

M Boğa, M Bingül, EE Özkan, H Şahin - Studies in natural products …, 2019 - Elsevier
indole alkaloids have been identified in the chemical profiles of Rauwolfia. The acridone
alkaloids … These indications have been associated with monoterpene indole alkaloids (MIAs). …

Indoles: as multitarget directed ligands in medicinal chemistry

N Chadha, O Silakari - Key heterocycle cores for designing multitargeting …, 2018 - Elsevier
… perfumes, pharmacologically active indole alkaloids, and some animal hormones such as
serotonin and melatonin. Some naturally occurring indole alkaloids have gained FDA approval…

[HTML][HTML] Antiviral activities of plant-derived indole and β-carboline alkaloids against human and avian influenza viruses

A Hegazy, SH Mahmoud, YAMM Elshaier… - Scientific Reports, 2023 - nature.com
… Herein, we screened the anti-influenza efficacy of some biologically active indole and β-carboline
(βC) indole alkaloids against two different influenza A viruses (IAV) with varied host …

Marine-derived fungi as a source of bioactive indole alkaloids with diversified structures

ZH Meng, TT Sun, GZ Zhao, YF Yue, QH Chang… - Marine Life Science & …, 2021 - Springer
… new indole alkaloids from … indole alkaloids isolated from marine-derived fungi during
1982–2019 (Supplementary Table S1). In conclusion, the discovery of novel active indole alkaloids

A review of the therapeutic importance of indole scaffold in drug discovery

N Teraiya, K Agrawal, TM Patel, A Patel… - Current Drug …, 2023 - ingentaconnect.com
… Monoterpenoid indole alkaloids with potential neuroprotective activities from the stems and
leaves of melodinus cochinchinensis neuroprotective activities from the stems and leaves of. …

Alkaloids as anticancer agents: a review of chinese patents in recent 5 years

H Tao, L Zuo, H Xu, C Li, G Qiao… - Recent Patents on Anti …, 2020 - ingentaconnect.com
… 1c), an indole alkaloid isolated from sponge Fascaplysinopsis sp., can interact with CDK4,
preventing cell division and proliferation [15]. Fascaplysin is capable of embedding in DNA …

Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?

DC Holland, AR Carroll - Natural Product Reports, 2023 - pubs.rsc.org
… activities for 2048 marine indole alkaloids (MIAs), a diverse sub-class of MNPs reported
up to the end of 2021, and this has highlighted that the bioactivity potentials for up to 86% of …

[HTML][HTML] Role of indole scaffolds as pharmacophores in the development of anti-lung cancer agents

J Dhuguru, R Skouta - Molecules, 2020 - mdpi.com
… Reserpine is a known indole alkaloid derived from the Rauwolfia serpentina plant. It has
been utilized as an anti-psychotic and anti-hypertensive agent to treat high blood pressure [24]. …