Harnessing the chemistry of the indole heterocycle to drive discoveries in biology and medicine
VM Norwood IV, RW Huigens III - ChemBioChem, 2019 - Wiley Online Library
… by molecular interactions between indole agent and critical therapeutic target. The chemical
… compounds of clinical use, complex indole alkaloids and indole-inspired discovery efforts …
… compounds of clinical use, complex indole alkaloids and indole-inspired discovery efforts …
[HTML][HTML] Protein kinases as therapeutic targets to develop anticancer drugs with natural alkaloids
H Ye, L Wang, L Ma, M Ionov, G Qiao… - Frontiers in Bioscience …, 2021 - imrpress.com
… 2), an indole alkaloid and isolated from Melodinus suaveolens, showed potent anticancer
effect against human promyelocytic leukemia HL-60, human liver cancer SMMC-7721, human …
effect against human promyelocytic leukemia HL-60, human liver cancer SMMC-7721, human …
Chemical and biological perspectives of monoterpene indole alkaloids from Rauwolfia species
… indole alkaloids have been identified in the chemical profiles of Rauwolfia. The acridone
alkaloids … These indications have been associated with monoterpene indole alkaloids (MIAs). …
alkaloids … These indications have been associated with monoterpene indole alkaloids (MIAs). …
Indoles: as multitarget directed ligands in medicinal chemistry
N Chadha, O Silakari - Key heterocycle cores for designing multitargeting …, 2018 - Elsevier
… perfumes, pharmacologically active indole alkaloids, and some animal hormones such as
serotonin and melatonin. Some naturally occurring indole alkaloids have gained FDA approval…
serotonin and melatonin. Some naturally occurring indole alkaloids have gained FDA approval…
[HTML][HTML] Antiviral activities of plant-derived indole and β-carboline alkaloids against human and avian influenza viruses
… Herein, we screened the anti-influenza efficacy of some biologically active indole and β-carboline
(βC) indole alkaloids against two different influenza A viruses (IAV) with varied host …
(βC) indole alkaloids against two different influenza A viruses (IAV) with varied host …
Marine-derived fungi as a source of bioactive indole alkaloids with diversified structures
ZH Meng, TT Sun, GZ Zhao, YF Yue, QH Chang… - Marine Life Science & …, 2021 - Springer
… new indole alkaloids from … indole alkaloids isolated from marine-derived fungi during
1982–2019 (Supplementary Table S1). In conclusion, the discovery of novel active indole alkaloids …
1982–2019 (Supplementary Table S1). In conclusion, the discovery of novel active indole alkaloids …
A review of the therapeutic importance of indole scaffold in drug discovery
… Monoterpenoid indole alkaloids with potential neuroprotective activities from the stems and
leaves of melodinus cochinchinensis neuroprotective activities from the stems and leaves of. …
leaves of melodinus cochinchinensis neuroprotective activities from the stems and leaves of. …
Alkaloids as anticancer agents: a review of chinese patents in recent 5 years
H Tao, L Zuo, H Xu, C Li, G Qiao… - Recent Patents on Anti …, 2020 - ingentaconnect.com
… 1c), an indole alkaloid isolated from sponge Fascaplysinopsis sp., can interact with CDK4,
preventing cell division and proliferation [15]. Fascaplysin is capable of embedding in DNA …
preventing cell division and proliferation [15]. Fascaplysin is capable of embedding in DNA …
Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?
DC Holland, AR Carroll - Natural Product Reports, 2023 - pubs.rsc.org
… activities for 2048 marine indole alkaloids (MIAs), a diverse sub-class of MNPs reported
up to the end of 2021, and this has highlighted that the bioactivity potentials for up to 86% of …
up to the end of 2021, and this has highlighted that the bioactivity potentials for up to 86% of …
[HTML][HTML] Role of indole scaffolds as pharmacophores in the development of anti-lung cancer agents
… Reserpine is a known indole alkaloid derived from the Rauwolfia serpentina plant. It has
been utilized as an anti-psychotic and anti-hypertensive agent to treat high blood pressure [24]. …
been utilized as an anti-psychotic and anti-hypertensive agent to treat high blood pressure [24]. …