Nephrotoxicity and Hepatotoxicity of Histamine H2 Receptor Antagonists

AA Fisher, DG Le Couteur - Drug safety, 2001 - Springer
… be more common in cimetidine-induced hepatotoxicity compared with ranitidine where a …
4 cases of cimetidine-induced hepatitis, 8 cases of ranitidine-induced hepatitis and in 1 patient …

Biochemical and histological studies on H2-receptor antagonist ranitidine-induced hepatotoxicity in rats

FAE Hemieda, ESK Abdei-Hady, MA Abou Elnga - 2005 - nopr.niscpr.res.in
… , Hepatotoxicity, Ranitidine, Rats, Serum Ranitidine hydrochloride (Zantac) is a potent Hzreceptors
antagonist, … in serum AM activity may be related to drug-induced liver injury. Zilva and …

Acute liver injury associated with the use of ebrotidine, a new H2-receptor antagonist

RJ Andrade, MI Lucena, R Martin-Vivaldi… - Journal of …, 1999 - Elsevier
… Background/Aim: Ebrotidine is a new H 2 -receptor antagonist marketed in Spain in early …
of acute liver injury related to ebrotidine and submitted to a Regional Registry of Hepatotoxicity

Hepatotoxic and hepatoprotective potential of histamine (H2)-receptor antagonists

M Black - The American journal of medicine, 1987 - Elsevier
… here, to treat acetaminophen hepatotoxicity. All HZ-receptor antagonists may not be alike in
this … although cimetidine protects against the hepatotoxic effects of acetaminophen, ranitidine …

The Role of Urotensin Receptors in the Paracetamol‐Induced Hepatotoxicity Model in Mice: Ameliorative Potential of Urotensin II Antagonist

SS Palabiyik, E Karakus, E Akpinar… - Basic & Clinical …, 2016 - Wiley Online Library
… UTR in PARA-induced hepatotoxicity and the inflammatory … UT-II agonist/antagonist on UT-II
expression and this receptor, … We showed UTR expression in PARA-induced hepatotoxicity

[PDF][PDF] 21 Nonsteroidal Anti-inflammatory Drugs and Leukotriene Receptor Antagonists: Pathology and Clinical Presentation of Hepatotoxicity

JH Lewis - Drug-induced liver disease, 2007 - repo.upertis.ac.id
… -induced hepatotoxicity. For instance, in Denmark, NSAIDs accounted for approximately 9%(97
of 1100) of all drug-related liver injury … The early history of NSAID-induced hepatic injury …

An in vitro study on 5-HT6 receptor antagonist induced hepatotoxicity based on biochemical assays and toxicogenomics

F Boess, E Durr, N Schaub, M Haiker, S Albertini… - Toxicology in Vitro, 2007 - Elsevier
… We investigated the effects of two 5-HT 6 receptor antagonists … While R7199 caused hepatic
steatosis in rats, no hepatotoxicity was … with regards to hepatotoxic potential. In particular, the …

Protective effect of Et-1 receptor antagonist bosentan on paracetamol induced acute liver toxicity in rats

M Yayla, Z Halici, B Unal, Y Bayir, E Akpinar… - European journal of …, 2014 - Elsevier
… We hypothesized that bosentan, which is a non-selective ET-1 receptor antagonist, can
prevent liver damage. This study included 49 female rats. Groups; I: Healthy group, II: …

Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation

Y Xie, CD Williams, MR McGill, M Lebofsky… - toxicological …, 2013 - academic.oup.com
… We conclude that the protective effect of the purinergic receptor antagonist A438079 against
APAP hepatotoxicity in vivo is mediated by affecting the metabolic activation of APAP and …

The TGFβ1 receptor antagonist GW788388 reduces JNK activation and protects against acetaminophen hepatotoxicity in mice

M McMillin, S Grant, G Frampton… - Toxicological …, 2019 - academic.oup.com
… of acetaminophen (APAP)-induced hepatotoxic liver injury with high rates of morbidity and …
during liver injury and influences hepatocyte senescence during APAP-induced hepatotoxicity