… MCP-1 chemokines in I/R induced inflammation damage. … inflammation and kidney damage
caused by LPS injection [37]. On the other hand, the effects of LOXblock-1 on inflammation …

… LoxBlock-1 on liver, pancreas, and cardiac dysfunction following Ischemia-Reperfusion-induced …
roles in explaining the mechanisms of renal inflammation. Current studies focus on new …

… LOXBlock-1, can specifically reduce 12/15-LOX activity in vivo, and provide efficient and
long-lasting protection against stroke-induced … , and LOXBlock-1 reduced hemispheric swelling, …

… In this study, we purpose to determine whether LOXBlock-1, a 12/15 lipoxygenase inhibitor,
… during neurodegenerative damage in synaptosomes induced by amyloid beta 1-42 (Aβ1-42)…

… local or organ-specific inflammatory processes. Disruption of … induced cell damage was
originally thought to be caused by … LOXBlock-1 (LB1; inhibitor of 15-LOX) [64] were applied. …

… , LOXblock-1, or vehicle, and then subjected to ischemia-reperfusion injury. LOXblock-1 blocks
… Consistent with this notion, our results show that LPS-induced inflammation in epithelial …

… induced inflammation augments vaccine immunity in part by recruiting APCs to vaccine draining
lymph nodes (LNs). However, the role of one APC subtype, inflammatory … with Lox block …

… More recently, we showed that NSAIDs induce expression of 15-LOX-1 in colorectal cancer
… 15-LOX-1 is critical to the induction of apoptosis by NSAIDs (7, 9). NSAIDs induce apoptosis …

… μg/mL) at day 40 post-induction in the presence or absence of 2 µM LOXBlock-1, an Alox12/15
… 6A), the addition of 2 µM LOXBlock-1, potently enhanced the effect of late-administered α-…

… , indicating that LOX blockade induced a more differentiated … a host of pro-inflammatory
substrates, called eicosanoids … studied, CD18, PANC-1 and Capan2. This was characterized …