… Taken together, we demonstrate that high sensitivity to cetuximab was strongly associated
with treatment-induced reduction in EGFR and pEGFR both in vivo and in vitro in a panel of …

… However, further research is warranted to elucidate the mechanisms behind the reduced
ADCC within our cetuximab-sensitive cell lines compared to the acquired resistant and intrinsic …

… cetuximab significantly reduced cancer proliferation in slices prepared from 2 tumors, it had
no effect in slices from 1 tumor, and even induced … No significant reduction in proliferation …

… Despite the cetuximab-induced increase in phosphorylation of EGFR and HER2, peak
EGF-induced levels of pEGFR and pHER2 were reduced by cetuximab in the cetuximab-sensitive …

… , reduce the downstream signaling pathways and induce EGFR … Cetuximab induces an
unexpected EGFR phosphorylation in … /AKT pathway restores sensitivity to cetuximab in HNSCC. …

… reduced cetuximab efficacy. CetuGEX, an antibody with optimized Fc glycosylation targeting
the same epitope as cetuximab, restored HNSCC sensitivity … , we studied induction of ADCC …

… of EGFR mediated by cetuximab induces G1-phase cell … G1 arrest and apoptosis in DiFi
cells by bFGF was sensitive to … SCC exposed to cetuximab presented a reduction in the release …

… irradiation sensitive cell lines showed a poor response to cetuximab, an EGFR inhibitor, and
SKI-II, a SphK1 inhibitor, and vice versa. In irradiation sensitive cells an enhanced reduction …

… cetuximab or 1 μM JAK1i for 8 or 24 h resulted in reduced activated STAT-3 (immunoblot),
and the combination treatment showed greater reduction … cetuximab sensitive and cetuximab …

… Here we hypothesized that cetuximab induces immunogenic … cells, which are highly sensitive
to cetuximab 15 . These cells are … We found that 4μ8c strongly reduced XBP1s transcription …