… induce ferroptosis of HT1080 cells via GPX4 inhibition and degradation. In summary, our
data revealed that the GPX4 degrader 8e … GPX4 inhibitor RSL3. Thus, an efficient strategy to …

… Unlike the previously reported GPX4 degrading agents, this study reported the potent
GPX4 PROTACs based on cIAP-E3 ligase for the first time. We found that when the linker was …

… peroxidase 4 (GPX4) and induces cancer cell ferroptosis. We … GPX4 degrader, dGPX4,
can deplete tumor cell GPX4 via … of ferroptosis induction efficiency compared to that of GPX4 …

… In summary, a potent and safe compound DC-2 has been found to induce GPX4 degradation
and subsequent ferroptosis. This study may have an important implication for the design of …

… , we investigated the kinetics of GPX4 degradation induced by 5i in … GPX4 was degraded
after 6 h treatment with 5i. Remarkably, over 80% of the GPX4 protein was effectively degraded …

… (26) Here, we designed two PDTACs by conjugating VPF with GPX4-targeting … nor degrading
activity. These PDTACs can selectively degrade GPX4 and dominantly induce ferroptotic …

… For example, the activation of NMD provides protection against apoptosis induced by
chemotherapeutic drugs by degrading the mRNA of pro-apoptotic genes (eg, growth arrest-specific …

… role in ferroptosis inducers (FINs)-induced glutathione peroxidase 4 (GPX4) degradation and
ferroptosis … Era-induced features of autophagy, GPX4 degradation, LPO, and subsequent …

… of inducing ferroptosis through ubiquitination of GPX4. Moreover, the mechanism of GPX4
… inactivation and iron oxidation [37] and FIN56 induced ferroptosis by degrading GPX4 with …

… GPX4 inhibition and ferroptosis induction [18]. Several reviews have summarized GPX4
regulation and ferroptosis induction … was discovered as a highly efficacious GPX4 degrader, 2–3 …