… inflammasome activation is vital for the host to cope with foreign pathogens or tissue damage,
while aberrant inflammasome activation … balance between inflammasome activation and …

… in turn, appears to bind to NLRP3 and to activate the NLRP3 inflammasome complex. However,
both mitochondrial ROS-dependent and -independent pathways are required for NLRP3 …

… activation of NLRP3, assembly of the inflammasome complex, and finally culminates in the
… The definitive mechanism for NLRP3 inflammasome activation remains elusive, but in the …

… NLRP3 inflammasome complex assembly. A better understanding of the molecular mechanisms
underlying NLRP3 inflammasome activation … of NLRP3 inflammasome-related diseases. …

… trigger, the NLRP3 inflammasome can be activated by a wide … of the mechanisms leading
to inflammasome activation is … complex, the caspase-1 activating multiprotein complex was …

… Therefore, the role of priming in NLRP3 activation is more complex than was originally
appreciated (Figure 1). Transcription-independent signaling of priming may further fine-tune …

… the inflammasome … inflammasome complex-forming capabilities. Here, we review these
recent advances that are shaping our understanding of the complex biology of the inflammasome …

… Most recently, discovery of the AIM2 inflammasome has revealed a new type of inflammasome
complex which does not contaim NLR proteins and binds to double stranded DNA directly…

… Given that NLRP3 activation … mechanism of this process. In this review, we summarize the
current knowledge on the molecular events that lead to activation of the NLRP3 inflammasome …

… Once activated the receptors form an inflammasome complex with or without the adaptor,
ASC, and recruit procaspase-1, which is subsequently cleaved into active caspase-1. Caspase-…