… 30) and tested their potential to activate microglia through PRR ligation. We further … activate
the NLRP3 inflammasome through TLR2 and TLR5 ligation, leading to NLRP3 inflammasome…

… Ligation of TLR5 by flagellin results in nuclear factor (NF)-κB-… Such inflammasome activation
results in the caspase-1-… to as inflammasome cytokines. The accumulated data indicate that …

… Collectively, this work suggests a biphasic mechanism for Nlrc4 inflammasome activation in
… TLR5 (34). However, whether H. pylori flagellin triggers Nlrc4 inflammasome activation is not …

… ) for inflammasome activation 9,10,11,12 . The NLRC4/NAIP5 inflammasome activates cysteine
… Restriction enzymes and DNA ligase were purchased from New England Biolabs, Inc. (…

… Inactive FlaTox that only engages TLR5 but not NAIP5 was … -length inserts were amplified
and ligated into the mTurquoise2-… insert was amplified and ligated between the AgeI and SalI …

… flagellin residue to TLR5 binding and activation has not been … and activate TLR5, we
performed structural and mutational studies of the flagellin-mediated TLR5 interaction and activation…

… be recognised at the cell surface by TLR5, but can also be sensed … of the E3 ubiquitin (Ub)
ligase, TNFR-associated factor 6 (… subsequent NLRP3 inflammasome activation by cholesterol …

… inflammasome activation of APCs, our study demonstrates that isolated autophagosomes
(DRibbles) from antigen donor cells activate inflammasomes … by CD40 ligation in the absence …

… NLRP3 inflammasome activation and associated peritonitis in the mouse model (Basic
Protocol 4). Alternatively, a method for inducing noncanonical NLRP3 inflammasome activation in …

… Here, this study demonstrate that the E3 ubiquitin ligase TRIM65 is an endogenous negative
regulator of NLRP3 inflammasome activation. TRIM65 was found to directly bind NLRP3 …