Pattern Recognition Receptors and Fulminant Myocarditis

DW Wang, R Zhou - Fulminant Myocarditis, 2022 - Springer
… apoptosis-associated speck-like protein, and promoting the formation of inflammasome [13]. …
may involve NLRP3 inflammasome activation. Thus, the NLRP3 inflammasome is critical in …

The Inflammasome in Acute Myocarditis

H Kannan - 2013 - scholarscompass.vcu.edu
… We hypothesized the formation of the inflammasome in acute myocarditis. To investigate, …
recovery with survival (fulminant myocarditis). If the inflammasome intensity should not …

[HTML][HTML] Myocarditis and inflammatory cardiomyopathy: current evidence and future directions

C Tschöpe, E Ammirati, B Bozkurt… - Nature Reviews …, 2021 - nature.com
… whereas others develop dilated cardiomyopathy is unclear. The … of myocarditis and
inflammatory cardiomyopathy, with a special focus on virus-induced and virus-associated myocarditis

[HTML][HTML] Roles of inflammasomes in viral myocarditis

J Xu, Z Zhou, Y Zheng, S Yang, K Huang… - Frontiers in Cellular and …, 2023 - frontiersin.org
… pro-caspase-1 and results in the formation of CARD8 inflammasome. (3) The caspase-11 …
was admitted to the hospital due to fulminant myocarditis. Because previous treatment was …

MG53 protects against Coxsackievirus B3-induced acute viral myocarditis in mice by inhibiting NLRP3 inflammasome-mediated pyroptosis via the NF-κB signaling …

Y Xue, T Song, J Ke, S Lin, J Zhang, Y Chen… - Biochemical …, 2024 - Elsevier
myocarditis (AVMC). Approximately 2.5 % of AVMC patients may develop into fulminant
myocarditis … and activated, which cleaves the pore-forming protein gasdermin D (GSDMD), pro-IL…

[HTML][HTML] Anakinra in pediatric acute fulminant myocarditis

L Maunier, R Charbel, V Lambert, P Tissières - Annals of Intensive Care, 2022 - Springer
… of eight children with acute fulminant myocarditis who received anakinra. … myocarditis,
formation of the inflammasome is a well-recognized pathogenic mechanism. Inflammasomes are a …

[HTML][HTML] Susceptibility to innate immune activation in genetically mediated myocarditis

DF Selgrade, DE Fullenkamp, IA Chychula, B Li… - The Journal of Clinical …, 2024 - jci.org
… the formation of intercellular junctions (37, 38). EHT modeling of DSP-related cardiomyopathy
… We also tested oridonin because it inhibits the NLRP3 inflammasome, a protein complex …

Management of acute myocarditis and chronic inflammatory cardiomyopathy: an expert consensus document

E Ammirati, M Frigerio, ED Adler, C Basso… - Circulation: Heart …, 2020 - Am Heart Assoc
… cell myocarditis* X Myocarditis characterized by large multinuclear cells infiltrating the heart
on histology (see text for details) in the absence of well-formed … with fulminant myocarditis; …

[HTML][HTML] Fulminant myocarditis: a comprehensive review from etiology to treatments and outcomes

W Hang, C Chen, JM Seubert, DW Wang - Signal transduction and …, 2020 - nature.com
Fulminant myocarditis (FM) is characterized by a rapid progressive decline in cardiac function
and a high mortality rate. Since the first report of FM patients in the 1980s, several clinical …

Clinical Characteristics and Mechanisms of Acute Myocarditis

S Heymans, S Van Linthout, SM Kraus… - Circulation …, 2024 - ahajournals.org
… (ie, fulminant myocarditis with cardiogenic shock and severely impaired LV function) and
life-threatening arrhythmia or conduction disturbances (eg, sustained ventricular arrhythmias, …