… to cause hypertension and end-organ damage. This review assesses these two paradigms
of Na + regulation in the context of inflammation-mediated hypertension and cardiovascular …

… the role of sodium and inflammation in the pathophysiology of hypertension and the observed
… A new paradigm of sodium regulation in inflammation and hypertension. Am J Physiol …

… hypertension. In recent years, several new advances were made in our understanding of the
interaction between sodium and blood pressure regulation. … to inflammation in hypertension. …

… the hypertensive response and attenuates renal sodium retention via a serum- and
glucocorticoid-regulated … extracellular sodium concentrations stimulate T lymphocytes to produce …

… IL-17 (due to enhanced generation and activity of TH17 cells) and decreased production
of anti-inflammatory bioactive lipids that have a negative regulatory control on IL-6 and TNF-α, …

… hypertension. He argued that through its functions to regulate volume homeostasis and sodium
… and that persistent hypertension reflected a failure of the kidney to appropriately excrete …

… focused on renal regulation of sodium (Na + ). Drs. Guyton and Coleman’s modeling posited
that salt would not raise BP unless there was a defect in the regulation of natriuresis and …

… Inflammatory effector mediators also alter renal sodium and … in the regulation of the initial
immune and inflammatory activation, … to end-organ mechanisms that regulate blood pressure. …

… several adverse effects, causing microvascular endothelial inflammation, anatomic remodeling,
and … intake is governed by neural mechanisms that regulate intake of sodium and related …

… dogma on body sodium balance and its regulation. Emerging evidence … sodium can directly
trigger an inflammatory response in antigen-presenting cells (APCs), leading to hypertension …