… addition to active cell-death caspases, lymphocytes from patients with sepsis have many other
… caspase-3 inhibitor decreased sepsis-induced apoptosis and improved survival in sepsis …

… , and their striking roles in sepsis have been focused elaborately in a number … caspases in
terms of apoptosis, pyroptosis, necroptosis and inflammation and focused their links in sepsis …

… cell death. Here, we review reports describing a role for caspase-1 in macrophage apoptosis
in response to infection by … , and a role for caspases-1 and -11 in neuronal apoptosis and …

… has led to a reevaluation of the model of sepsis and dysregulated systemic inflammation. …
The second main committed apoptotic event is the activation of caspase 3 (23) . Caspase …

… the inflammatory caspases play a direct role in apoptosis, as … both their execution of cell death
and their cellular “apoptotic” … the inflammatory caspases, their function in inflammation and …

… elevated blood levels of soluble caspase-1 in early septic shock represents in our opinion …
Caspase-1, the founding member of caspase family is predominantly involved in inflammation …

… helps explain the absence of inflammation associated with apoptosis. … role of caspases as
effectors of apoptosis came from the fact that overexpression of caspases induced apoptosis ( …

… caspase inhibition and the importance of apoptosis and inflammation in different models of
sepsis, we hypothesize that simultaneous activation of apoptotic cell death and inflammation …

… Infection and … inflammatory responses by interfering with caspase-1 activation and other
innate immune pathways. Here, we recapitulate the reported roles of inflammatory caspases …

… Summary Sepsis, a systemic inflammatory response to infection, … sepsis-induced lymphocyte
apoptosis and reduced lethality [42]. Caspase inhibitors have been used to block apoptosis …