Genetics and pathogenesis of inflammatory bowel disease

B Khor, A Gardet, RJ Xavier - Nature, 2011 - nature.com
… Family history is a risk factor for developing IBD, with a peak incidence in early adult life,
although individuals of any age can be affected. IBD is thought to result from an inappropriate …

Impact of genes and the environment on the pathogenesis and disease course of inflammatory bowel disease

M Zhao, J Burisch - Digestive diseases and sciences, 2019 - Springer
… In IBD, breastfeeding has been reported to yield protection against disease development
in a dose-dependent manner [38,39,40]. Notably, the strength of the association varies across …

A comprehensive review and update on the pathogenesis of inflammatory bowel disease

Q Guan - Journal of immunology research, 2019 - Wiley Online Library
… Patients with inflammatory bowel disease (IBD) are at increased risk for developing colorectal
cancer. It is been found that MDSC accumulation is further increased in the lesions during …

Disability in inflammatory bowel diseases: developing ICF Core Sets for patients with inflammatory bowel diseases based on the International Classification of …

L Peyrin-Biroulet, A Cieza, WJ Sandborn… - Inflammatory bowel …, 2010 - academic.oup.com
… The inflammatory bowel diseases (IBDs) are … specific disease given the environmental
context in which they live. The aim of this article is to outline the methods to be utilized to develop

[HTML][HTML] Predictors of aggressive inflammatory bowel disease

AJ Yarur, SG Strobel, AR Deshpande… - Gastroenterology & …, 2011 - ncbi.nlm.nih.gov
… As with diagnosis, we still do not have a reliable way to predict which patients will develop
more aggressive disease, but the combination of variables reviewed in this paper can help …

[HTML][HTML] Defining disease severity in inflammatory bowel diseases: current and future directions

L Peyrin-Biroulet, J Panés, WJ Sandborn… - Clinical …, 2016 - Elsevier
… Therefore, we propose developing a disease severity classification for IBD including the 3
develop a pragmatic means of classifying patients within the spectrum of disease severity. …

Inflammatory bowel disease: developing a short disease specific scale to measure health related quality of life

GD Smith, R Watson, KR Palmer - International journal of nursing studies, 2002 - Elsevier
Inflammatory bowel disease (IBD) is a general term for two idiopathic chronic diseases:
Crohn's disease (CD) and ulcerative colitis (UC) which are distinct, but related, inflammatory

[HTML][HTML] Cancer in inflammatory bowel disease

J Xie, SH Itzkowitz - World journal of gastroenterology: WJG, 2008 - ncbi.nlm.nih.gov
… Patients with long-standing inflammatory bowel disease (IBD) have an increased risk of
developing colorectal cancer (CRC). Many of the molecular alterations responsible for sporadic …

The histopathological approach to inflammatory bowel disease: a practice guide

C Langner, F Magro, A Driessen, A Ensari… - Virchows Archiv, 2014 - Springer
Inflammatory bowel diseases (IBDs) are lifelong disorders predominantly present in
developed countries. In their pathogenesis, an interaction between genetic and environmental …

The microbiota and inflammatory bowel disease: insights from animal models

JM Peloquin, DD Nguyen - Anaerobe, 2013 - Elsevier
… Presently, inflammatory bowel disease is thought to result from a loss of homeostasis between
… Additional mechanisms of colitis initiation include spontaneous disease development in …