NLRP3 inflammasome and inflammatory bowel disease

Y Zhen, H Zhang - Frontiers in immunology, 2019 - frontiersin.org
… against colitis. Here, … NLRP3 inflammasome in the intestinal, and we also discuss about
the complex interactions among the NLRP3 inflammasome, mucosal immune response and gut

Targeting NLRP3 inflammasome in inflammatory bowel disease: putting out the fire of inflammation

BZ Shao, SL Wang, P Pan, J Yao, K Wu, ZS Li, Y Bai… - Inflammation, 2019 - Springer
… , the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome is the …
NLRP3 inflammasome and IBD will be discussed. Furthermore, several NLRP3 inflammasome

The pathogenic role of NLRP3 inflammasome activation in inflammatory bowel diseases of both mice and humans

L Liu, Y Dong, M Ye, S Jin, J Yang… - … Crohn's and Colitis, 2017 - academic.oup.com
… the roles of NLRP3 inflammasome in the pathogenesis of inflammatory bowel disease in IL-…
the involvement of NLRP3 inflammasome in colonic inflammation. We demonstrated a time-…

Biological functions of NLRP3 inflammasome: A therapeutic target in inflammatory bowel disease

Y Song, Y Zhao, Y Ma, Z Wang, L Rong, B Wang… - Cytokine & Growth …, 2021 - Elsevier
… , the NLRP3 inflammasomeNLRP3 inflammasome is persistently activated during the
pathogenesis of IBD by multiple stimuli. Moreover, this protein complex regulates pro-inflammatory

Activation of NLRP3 inflammasome in inflammatory bowel disease: differences between Crohn's disease and ulcerative colitis

LD Lazaridis, A Pistiki… - Digestive diseases and …, 2017 - Springer
… Newer data claiming that increased IL-1β production through NLRP3 inflammasome pathway
… In conclusion, NLRP3 inflammasome is activated in patients with Crohn’s disease. Among …

[HTML][HTML] Role of NLRP3 inflammasome in inflammatory bowel diseases

E Tourkochristou, I Aggeletopoulou… - World journal of …, 2019 - ncbi.nlm.nih.gov
… Core tip: NLRP3 inflammasome plays a major role in inflammatory bowel diseases (IBD)
pathogenesis through its contribution to chronic inflammatory processes. Abnormal activation of …

The role of NLRP3 and IL-1β in the pathogenesis of inflammatory bowel disease

L Mao, A Kitani, W Strober, IJ Fuss - Frontiers in immunology, 2018 - frontiersin.org
… Returning now to studies of the effect of NLRP3 inflammasome defects on intestinal inflammation
we need to consider, as briefly mentioned above, a set of studies which show that such …

NLRP3 inflammasome in inflammatory bowel disease: friend or foe?

L Liu, X Li - Digestive diseases and sciences, 2017 - Springer
… The unsettling connection of the NLRP3 inflammasome … of the NLRP3 inflammasome against
oxazolone-induced colitis [… a pathogenic function of the NLRP3 inflammasome in IBD [3, 9]: …

[HTML][HTML] Targeting the NLRP3 inflammasome as new therapeutic avenue for inflammatory bowel disease

QL Chen, HR Yin, QY He, Y Wang - Biomedicine & Pharmacotherapy, 2021 - Elsevier
NLRP3 inflammasome activation serve as a feedback loop to further activate NLRP3
inflammasome under chronic disease condition… ] or low-density lipoprotein induce NLRP3-mediated …

Development of an acrylate derivative targeting the NLRP3 inflammasome for the treatment of inflammatory bowel disease

M Cocco, C Pellegrini… - Journal of Medicinal …, 2017 - ACS Publications
… we explored the use of direct NLRP3 inflammasome inhibitors as potential new tools for the
treatment of bowel inflammation. To design NLRP3 inhibitors suitable for further development…