The paradox of pro-inflammatory cytokines in cancer

CA Dinarello - Cancer and Metastasis Reviews, 2006 - Springer
… To explain the paradox of cytokines in host defense against cancer versus a role in the
initiation and progression of cancer, we can use the examples of the pro-inflammatory cytokines

Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage

SI Grivennikov, M Karin - Annals of the rheumatic diseases, 2011 - ard.bmj.com
… Another inflammation-linked cancer in which inflammatory cytokines have a significant role
… of liver cancer. HCC often develops in association with chronic liver inflammation caused by …

[HTML][HTML] Inflammatory cytokines in cancer: comprehensive understanding and clinical progress in gene therapy

T Lan, L Chen, X Wei - Cells, 2021 - mdpi.com
inflammation and cancer development, especially focusing on inflammatory cytokines. We
… for gene therapy targeting inflammatory cytokines for cancer treatment. Future perspectives …

Inflammatory cytokines in human pancreatic cancer

R Roshani, F McCarthy, T Hagemann - Cancer letters, 2014 - Elsevier
cytokine pathways has been shown to modulate PDAC progression and immune evasion;
therefore targeting cytokines … - and anti-inflammatory cytokines in pancreatic cancer and their …

Signal transduction of inflammatory cytokines and tumor development

A Yoshimura - Cancer science, 2006 - Wiley Online Library
… signaling pathways of inflammatory cytokines such as tumor … major roles in transmitting
inflammatory cytokine signals to the … that induce inflammatory mediators from inflammatory cells, …

The role of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugs

RM Logan, AM Stringer, JM Bowen, ASJ Yeoh… - Cancer treatment …, 2007 - Elsevier
… and pro-inflammatory cytokines in the development of mucositis.11, 12 The focus of this
review is to examine the literature relating to the role that pro-inflammatory cytokines might play …

Cancer inflammation and cytokines

MR Galdiero, G Marone… - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
… A number of soluble and cellular inflammatory mediators take part in the various phases of
cancer … TAMs and TANs are both integrated in cancer-related inflammation and an ever better …

IL-6 and ovarian cancer: inflammatory cytokines in promotion of metastasis

L Browning, MR Patel, EB Horvath… - Cancer management …, 2018 - Taylor & Francis
… -drug therapy siltuximab treatment in this study, and in other studies investigating the effects
of anti-IL-6 therapy in platinum-resistant ovarian cancer, suggests that IL-6 inhibition may …

Cytokines and their relationship to the symptoms and outcome of cancer

B Seruga, H Zhang, LJ Bernstein, IF Tannock - Nature Reviews Cancer, 2008 - nature.com
… , during and after treatment. In people with advanced cancer, pro-inflammatory cytokines are
… , toxicity of treatment and resistance to treatment. However, physical activity might modify …

Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer

SA Jones, BJ Jenkins - Nature reviews immunology, 2018 - nature.com
… with drugs that target the IL-6 pathway. Here, we discuss the emerging roles for IL-6 family
members in infection, chronic inflammation, autoimmunity and cancer and review therapeutic …