… of disease. Drawing on recent advances in understanding of the cGAS–STING pathway …
strategies that target this pathway and discuss their therapeutic potential in the treatment of …

… , and why and how cGAS–STING becomes activated in disease states. Finally, we consider
… cGAS–STING activation in inflammatory diseases or to stimulate inflammation in immune-…

… are associated with genetic mutations in regulatory genes of the cGAS-STING pathway. …
inflammatory disease, bear cutaneous lesions and harbour point mutations in exon 5 of STING (…

… of GI diseases. This review presents recent advances regarding the role of cGAS– STING
signaling pathway in GI inflammatory disease and … strategies targeting the signaling pathway. …

… Therefore, the current manuscript is to describe the cGAS-STING signaling pathway in …
Trex1 −/− mice exhibit inflammatory diseases including myocarditis and premature death due to …

… cGAS-STING is pivotal in modulating cellular inflammation, … -STING pathway onto more
diseases with inflammatory responses … -based diseases such as stroke, in which the inflammatory …

… Thus, self-DNA from the mitochondria or nucleus could also act as the cGAS ligand to
activate the cGAS-STING pathway in triggering inflammatory responses (16). Recent studies …

… Although most drugs are used in the treatment of tumors, they can be used as reference for
our treatment of other inflammatory diseases. 2′,3′ -cGAMP, as a natural CDN, conducts …

… diseases (Table 1). We summarize these sterile inflammatory diseases and discuss functions
of cGAS-STING signaling in each individual cell type and tissue involved in these diseases …

… cGAS–STING pathway to the development of a broad array of sterile inflammatory conditions
… how knowledge of this pathway is being leveraged to treat inflammatory diseases and to …