… canis or their components through direct or indirect pathways to produce active inflammatory
factors, which play an important role in host immunity. Currently, it has been found that the …

… pro-inflammatory factors produced upon activation of NLRP3 (for example, IL-18, HMGB1
and certain bioactive lipids) or pyroptosis, which may limit their effectiveness. Although just …

… ERS is also a key factor involved in NLRP3 inflammasome activation (Fig. 4). Studies show
that IRE1α activation increases mitochondrial ROS levels and promotes association between …

… Whereas Nlrp1, Nlrc4, and Aim2 are thought to be primarily involved in recognition of microbial
products, the Nlrp3 inflammasome also induces inflammatory responses towards certain …

… to be direct priming factors of the NLRP3 inflammasome. Additionally, … inflammation,
NLRP3 inflammasomes and insulin resistance. Regarding the role of the NLRP3 inflammasome …

… Age is one of the greatest “risk” factors for some of the most common chronic inflammatory
diseases, eg, atherosclerosis, metabolic syndrome, age-related macular degeneration (AMD), …

… In addition, caspase-1 is also one of the essential factors involved in an inflammatory form
of cell death termed pyroptosis (8). In summary, the components of NLRP3 inflammasome …

… inflammatory diseases in different cells and tissues. This article reviews the structure and
function of the NLRP3 inflammasome … chemical factors can activate the NLRP3 inflammasome, …

… promotes the release of cytokines and other inflammatory factors. Thus, NLRP3 inflammasome
is a vital player in innate immunity and inflammation and has been widely investigated in …

… initiate the transcriptional synthesis of various inflammatory factor precursors such as pro-IL-…
the NLRP3 inflammasome macromolecular complex which is assembled by NLRP3, ASC, …