Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors
ME Hamby, G Coppola, Y Ao… - Journal of …, 2012 - Soc Neuroscience
… Inflammation features in CNS disorders such as stroke, trauma, neurodegeneration, … which
astrocytes play critical roles. To elucidate how inflammatory mediators alter astrocyte functions…
astrocytes play critical roles. To elucidate how inflammatory mediators alter astrocyte functions…
The inflammatory transcriptome of reactive murine astrocytes and implications for their innate immune function
J Falsig, P Pörzgen, S Lund… - Journal of …, 2006 - Wiley Online Library
… Upon injury, astrocytes assume an activated state associated with the … of inflammatory
mediators. To model this, we stimulated murine primary astrocytes with a complete inflammatory …
mediators. To model this, we stimulated murine primary astrocytes with a complete inflammatory …
Multiple roles for astrocytes as effectors of cytokines and inflammatory mediators
MV Sofroniew - The Neuroscientist, 2014 - journals.sagepub.com
… For example, while analyzing the effects of cytokines and inflammatory mediators on astrocyte
transcriptome profiles, our attention was drawn to changes in numerous GPCRs and their …
transcriptome profiles, our attention was drawn to changes in numerous GPCRs and their …
Neuroinflammatory astrocyte subtypes in the mouse brain
… In this study, we investigated transcriptome changes of mouse cortical astrocytes after an
acute inflammatory stimulus using the bacterial cell wall endotoxin lipopolysaccharide. We …
acute inflammatory stimulus using the bacterial cell wall endotoxin lipopolysaccharide. We …
Transcriptome analysis reveals neuroprotective aspects of human reactive astrocytes induced by interleukin 1β
… It has been reported that among inflammatory mediators such as IL-1, TNF, IFN, and TGF, …
induction of reactive-astrocyte phenotype 8 . IL1β is a prominent inflammatory cytokine and is …
induction of reactive-astrocyte phenotype 8 . IL1β is a prominent inflammatory cytokine and is …
[HTML][HTML] Transcriptome analysis reveals disparate expression of inflammation-related miRNAs and their gene targets in iPSC-astrocytes from people with …
… following inflammatory challenge. Therefore, we modelled an inflammatory environment by
treating iPSC-astrocytes with IL-1β, a classical and prototypical pro-inflammatory cytokine, as …
treating iPSC-astrocytes with IL-1β, a classical and prototypical pro-inflammatory cytokine, as …
Identification of glial activation markers by comparison of transcriptome changes between astrocytes and microglia following innate immune stimulation
S Madeddu, TA Woods, P Mukherjee, D Sturdevant… - PLoS …, 2015 - journals.plos.org
… cells and cellular debris as well as producing inflammatory mediators [8, 9, 15]. In contrast
to microglia, … Excessive activation of astrocytes during infection or inflammation can result in …
to microglia, … Excessive activation of astrocytes during infection or inflammation can result in …
Heterogeneity of reactive astrocytes
MA Anderson, Y Ao, MV Sofroniew - Neuroscience letters, 2014 - Elsevier
… Gene array studies of astrocyte transcriptome profiles show that astrocytes can have very …
and other inflammatory mediators that can drive reactive astrocyte transcriptome profiles …
and other inflammatory mediators that can drive reactive astrocyte transcriptome profiles …
Transcriptomic profiling of microglia and astrocytes throughout aging
J Pan, N Ma, B Yu, W Zhang, J Wan - Journal of Neuroinflammation, 2020 - Springer
… associated with the inflammatory response, whereas these genes in astrocytes included
widely … To determine the aging transcriptomes in AD, we analyzed the expression of age-altered …
widely … To determine the aging transcriptomes in AD, we analyzed the expression of age-altered …
Effect of astrocyte‐targeted production of IL‐6 on traumatic brain injury and its impact on the cortical transcriptome
A Quintana, A Molinero, R Borup… - Developmental …, 2008 - Wiley Online Library
Interleukin‐6 (IL‐6) is one of the key players in the response of the brain cortex to injury. We
have described previously that astrocyte‐driven production of IL‐6 (GFAP‐IL6) in transgenic …
have described previously that astrocyte‐driven production of IL‐6 (GFAP‐IL6) in transgenic …
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