… Inflammation features in CNS disorders such as stroke, trauma, neurodegeneration, … which
astrocytes play critical roles. To elucidate how inflammatory mediators alter astrocyte functions…

… Upon injury, astrocytes assume an activated state associated with the … of inflammatory
mediators. To model this, we stimulated murine primary astrocytes with a complete inflammatory …

… For example, while analyzing the effects of cytokines and inflammatory mediators on astrocyte
transcriptome profiles, our attention was drawn to changes in numerous GPCRs and their …

… In this study, we investigated transcriptome changes of mouse cortical astrocytes after an
acute inflammatory stimulus using the bacterial cell wall endotoxin lipopolysaccharide. We …

… It has been reported that among inflammatory mediators such as IL-1, TNF, IFN, and TGF, …
induction of reactive-astrocyte phenotype 8 . IL1β is a prominent inflammatory cytokine and is …

… following inflammatory challenge. Therefore, we modelled an inflammatory environment by
treating iPSC-astrocytes with IL-1β, a classical and prototypical pro-inflammatory cytokine, as …

… cells and cellular debris as well as producing inflammatory mediators [8, 9, 15]. In contrast
to microglia, … Excessive activation of astrocytes during infection or inflammation can result in …

… Gene array studies of astrocyte transcriptome profiles show that astrocytes can have very …
and other inflammatory mediators that can drive reactive astrocyte transcriptome profiles …

… associated with the inflammatory response, whereas these genes in astrocytes included
widely … To determine the aging transcriptomes in AD, we analyzed the expression of age-altered …

Interleukin‐6 (IL‐6) is one of the key players in the response of the brain cortex to injury. We
have described previously that astrocyte‐driven production of IL‐6 (GFAP‐IL6) in transgenic …