The formalin test in mice: dissociation between inflammatory and non-inflammatory pain

S Hunskaar, K Hole - Pain, 1987 - journals.lww.com
… of formalin. In order to elucidate the involvement of inflammatory processes in the two phases,
we tested … In contrast, the non-steroid anti-inflammatory drugs indomethacin and naproxen …

Modified formalin test: characteristic biphasic pain response

M Shibata, T Ohkubo, H Takahashi, R Inoki - pain, 1989 - Elsevier
… obtaining neurogenic inflammation [l] and continuous pain. We previously modified the
formalin test in mice, using the forepaw as the site of formalin injection, and simplified the pain rat…

Peripheral opioid modulation of pain and inflammation in the formalin test

Y Hong, FV Abbott - European journal of pharmacology, 1995 - Elsevier
formalin pain was unexpected. It is possible that the net effect of ~-opioid receptor agonists
on inflammatory pain … secondary to the anti-inflammatory actions may be more significant. In a …

The formalin test: characteristics and usefulness of the model

J Sawynok, XJ Liu - Reviews in analgesia, 2003 - ingentaconnect.com
… The formalin test was introduced as a model of tonic pain in 1977, and has since been used
… The formalin test was originally introduced as a model of tonic pain involving inflammation, …

Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat.

AB Malmberg, TL Yaksh - Journal of Pharmacology and Experimental …, 1992 - ASPET
… and ASA), the highest dose of drug which was used in the formalin test was given it and the
effect upon the HP (52.5#{176}C)response latency was assessed. Systemic action ofNSAID. …

The formalin test does not probe inflammatory pain but excitotoxicity in rodent skin

T Hoffmann, F Klemm, TI Kichko, SK Sauer… - Physiological …, 2022 - Wiley Online Library
… pigs show biphasic pain in the formalin test, whereas larger … by our recent work on the
formalin test. However, it provided … in pain-related behavior around eight minutes after formalin

The rat paw formalin test: comparison of noxious agents

H Wheeler-Aceto, F Porreca, A Cowan - Pain, 1990 - Elsevier
… and kaolin are sensitive to anti-inflammatory … potential pain-producing agents tested formalin
was the best. It produced the most robust spontaneous response, ideal for analgesic testing

Inflammation-susceptible Lewis rats show less sensitivity than resistant Fischer rats in the formalin inflammatory pain test and with repeated thermal testing

WR Lariviere, MA Sattar… - Journal of …, 2006 - journals.physiology.org
… of a nonspecific response to painful inflammatory stimuli. This study remained … formalin test
results of this study are also important because the strain differences in baseline inflammatory

The formalin test in mice: effect of formalin concentration

JH Rosland, A Tjølsen, B Mæhle, K Hole - Pain, 1990 - journals.lww.com
… of pain were postulated: a short-lasting pain caused by a direct effect on nociceptors followed
… a longer lasting pain due to inflammation. Other studies have confirmed that inflammation

… effects of anti-inflammatory drugs in the formalin test in rats: separate mechanisms underlying the nociceptive effects of low-and high-concentration formalin

K Yashpal, TJ Coderre - European Journal of Pain, 1998 - Elsevier
… and inflammatory effects of formalin in the rat hind paw. However, only a high concentration
of formalin, … of anti-inflammatory agents, and the effects are restricted to the late phase of the …