Overexpression of MicroRNA16 Alleviates Atherosclerosis by Inhibition of Inflammatory Pathways

M Wang, J Li, J Cai, L Cheng, X Wang… - BioMed Research …, 2020 - Wiley Online Library
inflammatory roles. These findings indicated miR-16 may be an anti-atherogenic and CAD
miRNA… The goal of this study was to further validate the expression of miR-16 in CAD patients …

MicroRNA-16 suppresses the activation of inflammatory macrophages in atherosclerosis by targeting PDCD4

X Liang, Z Xu, M Yuan, Y Zhang… - International …, 2016 - spandidos-publications.com
… /ERK-c-Maf pathway (16) Consistently, in the present study, miR-16 markedly increased the
… p38/ERK-c-Maf pathway may be involved in the miR-16 mediated inflammatory response in …

[HTML][HTML] The role of microRNA-16 in the pathogenesis of autoimmune diseases: A comprehensive review

L Yan, M Liang, X Hou, Y Zhang, H Zhang… - Biomedicine & …, 2019 - Elsevier
… mRNA expression of the anti-inflammatory factor IL-10 [12]. miR-16 plays an important role
in inflammation-induced insulin sensitivity, and miR-16 improves insulin sensitivity via the …

MicroRNA16 inhibits interleukin‑13‑induced inflammatory cytokine secretion and mucus production in nasal epithelial cells by suppressing the IκB kinase β/nuclear …

Y Gao, Z Yu - Molecular Medicine Reports, 2018 - spandidos-publications.com
16‑mediated inhibitory effects on inflammatory response. These findings suggested that miR‑16
suppressed the inflammatory … inhibiting the activation of IKKβ/NF‑κB signaling pathways. …

MicroRNA-16 inhibits the TLR4/NF-κB pathway and maintains tight junction integrity in irritable bowel syndrome with diarrhea

M Xi, P Zhao, F Li, H Bao, S Ding, L Ji, J Yan - Journal of Biological …, 2022 - ASBMB
… cells, inflammation, and epithelial tight junction. We found that miR-16 overexpression …
tight junction integrity, and inhibited cell apoptosis and inflammation. We showed that miR-…

[HTML][HTML] Identification of microRNA-16-5p and microRNA-21-5p in feces as potential noninvasive biomarkers for inflammatory bowel disease

R Zhou, P Qiu, H Wang, H Yang, X Yang, M Ye… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
… , inflammation, and fibrosis associated with IBD [14–16]. … fecal miRNA expression profile
from IBD patients and healthy controls (HC) were compared to recognize novel potential miRNA

MicroRNA-16 is putatively involved in the NF-κB pathway regulation in ulcerative colitis through adenosine A2a receptor (A2aAR) mRNA targeting

T Tian, Y Zhou, X Feng, S Ye, H Wang, W Wu, W Tan… - Scientific reports, 2016 - nature.com
… miR-16 … -16 on the activation of the NF-κB signaling pathway were confirmed by the A2aAR
knockdown assay. Our results suggest that miR-16 regulated the immune and inflammatory

[HTML][HTML] MicroRNA-16 inhibits the lipopolysaccharide-induced inflammatory response in nucleus pulposus cells of the intervertebral disc by targeting TAB3

K Du, X He, J Deng - Archives of Medical Science: AMS, 2021 - ncbi.nlm.nih.gov
… -16 is relevant to immunoregulation [14]. Based on the above findings, we hypothesized that
miR-16 … the role of miR-16 in regulating the LPS-induced inflammatory response of NP cells, …

MicroRNA16 regulates lipopolysaccharide‑induced inflammatory factor expression by targeting TLR4 in normal human bronchial epithelial cells

X Li, Q Chu, H Wang - Experimental and Therapeutic …, 2021 - spandidos-publications.com
… It was previously found that upregulation miR-16 can inhibit the inflammatory response in a
… -16 upregulation can attenuate the ALI-induced inflammatory responses. The role of miR-16

MicroRNA 16-5p is upregulated in calorie-restricted mice and modulates inflammatory cytokines of macrophages

K Yamada, S Takizawa, Y Ohgaku, T Asami, K Furuya… - Gene, 2020 - Elsevier
… -16-5p in serum and colon. Additionally, using a macrophage cell line, RAW264 cells,
transfected with miR-16-5p mimic, we showed that this miRNA regulates inflammatory cytokines. …