Inflection points in sepsis biology: from local defense to systemic organ injury

EJ Seeley, MA Matthay… - American Journal of …, 2012 - journals.physiology.org
… However, systemic spread of inflammation beyond a single focus leads to organ injury and
higher … in combating local infections yet can induce organ injury during systemic infection. …

Abdominal compartment syndrome in traumatic hemorrhagic shock: is there a fluid resuscitation inflection point associated with increased risk?

JO Hwabejire, CE Nembhard, TA Oyetunji… - The American Journal of …, 2016 - Elsevier
… In our analysis, all patients aged ≥16 years whose injuries or … lactate, Marshall's multiple
organ dysfunction score [MODS]) … primary end point was the fluid resuscitation inflection point, …

The mortality inflection point for age and acute cervical spinal cord injury

ND Martin, JA Marks, J Donohue… - Journal of Trauma …, 2011 - journals.lww.com
… In other words, the observed “inflection point” of 75 years may be less the result of treatable
and potentially reversible infection or organ system dysfunction and more the result of “…

End-expiratory esophageal pressure versus lower inflection point in acute lung injury

A Yaroshetskiy, D Protsenko, E Larin, O Ignatenko… - Critical Care, 2013 - Springer
… Conclusion Autophagy was induced in several organs over … Our data suggest autophagy
plays a protective role in organ … production and minimizes tissue injury during inflammation. …

Lung and'end organ'injury due to mechanical ventilation in animals: comparison between the prone and supine positions

G Nakos, A Batistatou, E Galiatsou, E Konstanti… - Critical Care, 2006 - Springer
injury but it can also result in dependent atelectasis. A positive end expiratory pressure above
the inflection point … Furthermore, it is conceivable that at some point in the future we will be …

The position of the lower inflection point depends on volume history

H Knorpp, M Lichtwarck-Aschoff, C Stahl, S Schumann… - Critical Care, 2006 - Springer
… nuclear fragment or cell organ formed by invagination of the … rats revealed lung endothelial
cell injury manifested by the … rat pancreatitis model lung injury occurred early, between 2 …

Automatic Identification of Inflection Points in Pressure and Regional EIT curves

R Bhanabhai, I Frerichs, S Pulletz… - CMBES …, 2012 - proceedings.cmbes.ca
… The lung is an essential organ within the respiratory system with its main function being the
transport of oxygen into the … of the pressure-volume curve in acute lung injury,” Am. J. Respir. …

Different low constant flows can equally determine the lower inflection point in acute respiratory distress syndrome patients

AMCN Gama, EC Meyer, AMAS Gaudêncio… - … organs, 2001 - Wiley Online Library
… CFs (1, 2, 5, and 10 L/min) on determination of lower inflection point of the P × V curve (L‐Pflex)
and upper inflection point of the P × V curve (U‐Pflex) on the maximum slope and on the …

Ventilator-induced lung injury

JD Ricard, D Dreyfuss, G Saumon - Current opinion in critical care, 2002 - journals.lww.com
… the syndrome of multiple organ failure. Loss … inflection point, easily identifiable in the lowest
curve (broken arrow). A second upper inflection point is found above the lower inflection point

Ventilator-induced lung injury

JD Ricard, D Dreyfuss… - European respiratory …, 2003 - Eur Respiratory Soc
… Alterations in the respiratory system pressure/volume curve during ventilator-induced lung
injury that include decrease in compliance and position of the upper inflection point are due to …