Pharmacological inhibition of acid sphingomyelinase prevents uptake of SARS-CoV-2 by epithelial cells

A Carpinteiro, MJ Edwards, M Hoffmann, G Kochs… - Cell Reports …, 2020 - cell.com
inhibition of acid … syndrome coronavirus 2 (SARS-CoV-2) or vesicular stomatitis virus (VSV)
pseudoviral particles (pp-VSV) presenting SARS-CoV-2 spike protein (pp-VSV-SARS-CoV-2 …

Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells

A Carpinteiro, B Gripp, M Hoffmann, S Pöhlmann… - Journal of Biological …, 2021 - ASBMB
… -VSV-SARS-CoV-2 spike required activation of acid sphingomyelinase … acid sphingomyelinase
activity in nasal epithelial cells and prevented pp-VSV-SARS-CoV-2 spike-induced acid

[HTML][HTML] Repurposing functional inhibitors of acid sphingomyelinase (fiasmas): an opportunity against SARSCoV‐2 infection?

P Le Corre, G Loas - Journal of Clinical Pharmacy and …, 2021 - ncbi.nlm.nih.gov
… to evaluate the rationale for repurposing functional inhibitors of acid sphingomyelinase (FIASMAs),
several of which are approved medicines, for the treatment of SAR‐CoV‐2 infections. …

Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication

J Chu, C Xing, Y Du, T Duan, S Liu, P Zhang… - Nature …, 2021 - nature.com
acid synthase inhibitors as drug candidates for the prevention and treatment of COVID-19 by
inhibiting SARS-CoV-… suggest that FAS inhibitors can potently inhibit SARS-CoV-2 infection …

Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant …

S Schloer, L Brunotte, J Goretzko… - Emerging microbes & …, 2020 - Taylor & Francis
… host-pathogen interface, to fight SARS-CoV-2 infection. We find that fluoxetine, … inhibitor of
acid sphingomyelinase (FIASMA), efficiently inhibited the entry and propagation of SARS-CoV-…

Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication

CG Williams, AS Jureka, JA Silvas, AM Nicolini… - Cell reports, 2021 - cell.com
inhibitors that target the PI3 kinase VPS34 or fatty acid metabolism for anti-severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-… are potent SARS-CoV-2 inhibitors. Mechanistic …

Inhibitory activity of quercetin, its metabolite, and standard antiviral drugs towards enzymes essential for SARS-CoV-2: The role of acid–base equilibria

ŽB Milanović, MR Antonijević, AD Amić, EH Avdović… - RSC …, 2021 - pubs.rsc.org
inhibitory effect against the SARS-CoV-2 furin enzyme and spiked glycoprotein through different
acid… potential therapeutic agents in the fight against the SARS-CoV-2 virus. On the other …

Folic acid: A potential inhibitor against SARS-CoV-2 nucleocapsid protein

YM Chen, JL Wei, RS Qin, JP Hou, GC Zang… - Pharmaceutical …, 2022 - Taylor & Francis
acid was screened as a potential new drug. Moreover, molecular docking showed folic acid
could target on SARS-CoV… RNAi to verify whether folic acid antagonises SARS-CoV-2 N. Cell…

The acid ceramidase is a SARS-CoV-2 host factor

N Geiger, L Kersting, J Schlegel, L Stelz, S Fähr… - Cells, 2022 - mdpi.com
… In this study, we identified an additional ASM-independent inhibition of SARS-CoV-2
replication by a fluoxetine derivative compared to previous studies. Furthermore, we show that the …

Potent and selective inhibition of SARS coronavirus replication by aurintricarboxylic acid

R He, A Adonov, M Traykova-Adonova, J Cao… - Biochemical and …, 2004 - Elsevier
… The newly identified SARS coronavirus (SARS-CoV) can be transmitted … acid (ATA) on
SARS-CoV replication in cell culture, and found that ATA could drastically inhibit SARS-CoV