Pharmacological inhibition of acid sphingomyelinase prevents uptake of SARS-CoV-2 by epithelial cells
A Carpinteiro, MJ Edwards, M Hoffmann, G Kochs… - Cell Reports …, 2020 - cell.com
… inhibition of acid … syndrome coronavirus 2 (SARS-CoV-2) or vesicular stomatitis virus (VSV)
pseudoviral particles (pp-VSV) presenting SARS-CoV-2 spike protein (pp-VSV-SARS-CoV-2 …
pseudoviral particles (pp-VSV) presenting SARS-CoV-2 spike protein (pp-VSV-SARS-CoV-2 …
Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells
A Carpinteiro, B Gripp, M Hoffmann, S Pöhlmann… - Journal of Biological …, 2021 - ASBMB
… -VSV-SARS-CoV-2 spike required activation of acid sphingomyelinase … acid sphingomyelinase
activity in nasal epithelial cells and prevented pp-VSV-SARS-CoV-2 spike-induced acid …
activity in nasal epithelial cells and prevented pp-VSV-SARS-CoV-2 spike-induced acid …
[HTML][HTML] Repurposing functional inhibitors of acid sphingomyelinase (fiasmas): an opportunity against SARS‐CoV‐2 infection?
P Le Corre, G Loas - Journal of Clinical Pharmacy and …, 2021 - ncbi.nlm.nih.gov
… to evaluate the rationale for repurposing functional inhibitors of acid sphingomyelinase (FIASMAs),
several of which are approved medicines, for the treatment of SAR‐CoV‐2 infections. …
several of which are approved medicines, for the treatment of SAR‐CoV‐2 infections. …
Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication
… acid synthase inhibitors as drug candidates for the prevention and treatment of COVID-19 by
inhibiting SARS-CoV-… suggest that FAS inhibitors can potently inhibit SARS-CoV-2 infection …
inhibiting SARS-CoV-… suggest that FAS inhibitors can potently inhibit SARS-CoV-2 infection …
Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant …
S Schloer, L Brunotte, J Goretzko… - Emerging microbes & …, 2020 - Taylor & Francis
… host-pathogen interface, to fight SARS-CoV-2 infection. We find that fluoxetine, … inhibitor of
acid sphingomyelinase (FIASMA), efficiently inhibited the entry and propagation of SARS-CoV-…
acid sphingomyelinase (FIASMA), efficiently inhibited the entry and propagation of SARS-CoV-…
Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication
… inhibitors that target the PI3 kinase VPS34 or fatty acid metabolism for anti-severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-… are potent SARS-CoV-2 inhibitors. Mechanistic …
respiratory syndrome coronavirus 2 (SARS-CoV-… are potent SARS-CoV-2 inhibitors. Mechanistic …
Inhibitory activity of quercetin, its metabolite, and standard antiviral drugs towards enzymes essential for SARS-CoV-2: The role of acid–base equilibria
… inhibitory effect against the SARS-CoV-2 furin enzyme and spiked glycoprotein through different
acid… potential therapeutic agents in the fight against the SARS-CoV-2 virus. On the other …
acid… potential therapeutic agents in the fight against the SARS-CoV-2 virus. On the other …
Folic acid: A potential inhibitor against SARS-CoV-2 nucleocapsid protein
YM Chen, JL Wei, RS Qin, JP Hou, GC Zang… - Pharmaceutical …, 2022 - Taylor & Francis
… acid was screened as a potential new drug. Moreover, molecular docking showed folic acid
could target on SARS-CoV… RNAi to verify whether folic acid antagonises SARS-CoV-2 N. Cell…
could target on SARS-CoV… RNAi to verify whether folic acid antagonises SARS-CoV-2 N. Cell…
The acid ceramidase is a SARS-CoV-2 host factor
N Geiger, L Kersting, J Schlegel, L Stelz, S Fähr… - Cells, 2022 - mdpi.com
… In this study, we identified an additional ASM-independent inhibition of SARS-CoV-2
replication by a fluoxetine derivative compared to previous studies. Furthermore, we show that the …
replication by a fluoxetine derivative compared to previous studies. Furthermore, we show that the …
Potent and selective inhibition of SARS coronavirus replication by aurintricarboxylic acid
R He, A Adonov, M Traykova-Adonova, J Cao… - Biochemical and …, 2004 - Elsevier
… The newly identified SARS coronavirus (SARS-CoV) can be transmitted … acid (ATA) on
SARS-CoV replication in cell culture, and found that ATA could drastically inhibit SARS-CoV …
SARS-CoV replication in cell culture, and found that ATA could drastically inhibit SARS-CoV …
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