… as molecules have been identified. These research efforts have led to the development of a
new generation of small molecule inhibitors. … events downstream of cytokine receptors and …

… The advantage of small molecules (SMs) over biological therapies includes their lack of …
) inhibition has emerged as a novel strategy to modulate downstream cytokine signaling …

… small-molecule inhibitor of tumor necrosis factor α (TNF-α) that promotes subunit disassembly
of this trimeric cytokine … -based assays with median inhibitory concentrations of 22 and 4.6 …

… A small molecule inhibitor of NF-κB-dependent cytokine … Ro106-9920 was observed to
inhibit an ubiquitination activity that … as a time-dependent inhibitor of IκBαee ubiquitination with …

… In 1994, a pair of novel Ser/Thr protein kinases was identified as the molecular target for
pyridinyl imidazole inhibitors of cytokine release [5]. These kinases are homologues to the MAP …

… for inhibition of TNF family cytokines, and potentially also other constitutively oligomeric
proteins, by small molecule inhibitors. … , be easier to inhibit with a small molecule than are lower …

… self-renewal as well as inhibition of differentiation [5, 21]. In order to overcome this limitation,
we have identified a cocktail of three small molecules and four cytokines, named as the SC …

… specific proteins, including cytokines, MMPs, adhesion molecules, and growth factor receptor
genes [58-62]. In general, Curcumin acts through the inhibition of phosphorylation of the IκB…

… In this study, screening for new small-molecule inhibitors of NO and inflammatory cytokines
… potent inhibitory effect on the production of inflammatory cytokines such as TNF-α and IL-6 as …

… cytokines. In this review, we focus on chronic inflammatory skin diseases where cytokines
using type I/II cytokine … and where novel treatments with inhibitors of the JAK/STAT pathway …