Inhibition of DNA methylation in the developing rat brain disrupts sexually dimorphic neurobehavioral phenotypes in adulthood

Y Li, Q Ma, C Dasgupta, S Halavi, RE Hartman… - Molecular …, 2017 - Springer
… of inhibition of neonatal brain DNA methylation on a series of neurobehavioral phenotypes
in … Herein, we present novel evidence that DNA methylation profiles in the developing brain …

Effects of pharmacologic treatment for neonatal abstinence syndrome on DNA methylation and neurobehavior: a prospective cohort study

M Camerota, JM Davis, LM Dansereau… - The Journal of …, 2022 - Elsevier
… NAS is associated with decreased DNAm of the OPRM1 gene and improved neonatal
neurobehavior. Epigenetic changes may play a role in these changes in neonatal neurobehavior. …

Inhibition of DNA methylation with zebularine alters lipopolysaccharide-induced sickness behavior and neuroinflammation in mice

SM Matt, JD Zimmerman, MA Lawson… - Frontiers in …, 2018 - frontiersin.org
… investigate whether central DNMT inhibition by zebularine causes … DNMT inhibition would
lead to decreased Il-1β DNA methylation … Last, since DNA methylation affects other epigenetic …

Differences in DNA methylation reprogramming underlie the sexual dimorphism of behavioral disorder caused by prenatal stress in rats

L Lei, X Wu, H Gu, M Ji, J Yang - Frontiers in Neuroscience, 2020 - frontiersin.org
… The persistence of phenotypesinhibitor decitabine further demonstrated that the
neurodevelopmental abnormalities caused by PS in female but not male rats are DNA methylation-…

Long-term parental methamphetamine exposure of mice influences behavior and hippocampal DNA methylation of the offspring

Y Itzhak, I Ergui, JI Young - Molecular psychiatry, 2015 - nature.com
… utero METH exposure on neurobehavioral effects in adolescence … phenotypes across the
life course. Our results suggest that the aberrant behavioral phenotypes and DNA methylation

DNA methylome perturbations: an epigenetic basis for the emergingly heritable neurodevelopmental abnormalities associated with maternal smoking and maternal …

JM Buck, L Yu, VS Knopik, JA Stitzel - Biology of Reproduction, 2021 - academic.oup.com
… modulatory influences on an array of neurobehavioral phenotypes relevant to NDDs as well
… may facilitate neurobehavioral deficits in part via excessive inhibition of inhibitory neurons …

Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice

BI Laufer, K Mantha, ML Kleiber… - Disease models & …, 2013 - journals.biologists.com
… been implicated in FASD-relevant neurobehavioral phenotypes such as cognitive function,
… to examine how the variability seen in FASD phenotypes relates to the timing of alcohol …

Effects of global DNA methylation changes on neurobehavior in zebrafish

M Pickens - 2015 - search.proquest.com
neurobehavior phenotypes found in this study can be strongly associated with DNA methylation
… reduced sperm function and selective inhibition of de novo DNA methylation. Journal of …

Altered DNA methylation in the developing brains of rats genetically prone to high versus low anxiety

CR McCoy, ME Glover, LT Flynn… - Journal of …, 2019 - Soc Neuroscience
… HR/LR neurobehavioral phenotypes. Here we report altered … [LRs]) are highly inhibited in
novel situations and display high … neural DNA methylation patterns constitute a key phenotype-…

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

T Jia, C Chu, Y Liu, J Van Dongen, E Papastergios… - Molecular …, 2021 - nature.com
… The brain phenotypes examined in this study are from the ENIGMA analysis of high-resolution
MRI brain scans of volumetric measures (full details in [18]). Our analyses were focussed …