Inhibition of MAPK Kinase Signaling Pathways Suppressed Renal Cell Carcinoma Growth and Angiogenesis In vivo

D Huang, Y Ding, WM Luo, S Bender, CN Qian, E Kort… - Cancer research, 2008 - AACR
… RCC cells was dramatically inhibited by … inhibition of proliferation of endothelial cells in
vitro. Our results suggest that suppression of one or more MAPK signaling pathways may inhibit

Microtubule inhibitors elicit differential effects on MAP kinase (JNK, ERK, and p38) signaling pathways in human KB-3 carcinoma cells

AA Stone, TC Chambers - Experimental cell research, 2000 - Elsevier
… vival and cell death, we examined the extent and kinetics of activation of JNK, ERK, and p38
MAPKs in response to treatment of KB-3 carcinoma cells with several microtubule inhibitors. …

Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells

DB Reardon, JN Contessa, RB Mikkelsen, K Valerie… - Oncogene, 1999 - nature.com
cell proliferation and potentiating apoptosis. In summary, this data demonstrates that both
MAPK … downstream activation of MAPK which may affect the radiosensitivity of carcinoma cells. …

Inhibition of Aurora-A suppresses epithelial–mesenchymal transition and invasion by downregulating MAPK in nasopharyngeal carcinoma cells

XB Wan, ZJ Long, M Yan, J Xu, LP Xia, L Liu… - …, 2008 - academic.oup.com
MAPK phosphorylation and induced EMT ( 11 ). Conversely, inhibition of MAPK upstream
component MEK by inhibitor U0126 reversed this phenotype and reconstructed the tight cell

… -induced mitogen-activated protein (MAP) kinase activation in DU145 prostate carcinoma cells: MAP kinase inhibition enhances radiation-induced cell killing and G2 …

M Hagan, L Wang, JR Hanley, JS Park… - Radiation …, 2000 - meridian.allenpress.com
… Further, after irradiation, MAPK inhibition reduces clonogenic … cells become dependent on
MAPK activation for cell cycle progression. MAPK inhibition results in profound apparent cell

PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI3K/AKT/mTOR pathways

R Gedaly, P Angulo, J Hundley, MF Daily… - Anticancer …, 2010 - ar.iiarjournals.org
… The novel anticancer agent sorafenib is a multi-kinase inhibitor of more than a dozen … been
shown to inhibit tumor cell proliferation by blocking the Ras/Raf/MAPK pathway and to inhibit

The p38 MAPK inhibitors for the treatment of inflammatory diseases and cancer

HY Yong, MS Koh, A Moon - Expert opinion on investigational …, 2009 - Taylor & Francis
… p38α and p38β specifically induced the malignant phenotype of squamous cell
carcinoma cells by regulating cell survival, proliferation and invasion, suggesting these p38 …

[HTML][HTML] Rapid inhibition of MAPK signaling and anti-proliferation effect via JAK/STAT signaling by interferon-α in hepatocellular carcinoma cell lines

K Inamura, Y Matsuzaki, N Uematsu, A Honda… - … (BBA)-Molecular Cell …, 2005 - Elsevier
… IFN-α via the MAPK pathway in human HCC cell lines. Using … and ERK and blocked the
inhibition of phosphorylation of MEK … the MAPK pathway with rapid inhibition of MAPK signaling …

Role of Rho/ROCK and p38 MAP kinase pathways in transforming growth factor-β-mediated Smad-dependent growth inhibition of human breast carcinoma cells in …

AK Kamaraju, AB Roberts - Journal of Biological Chemistry, 2005 - ASBMB
… We demonstrate that activation of the p38 MAP kinase pathway is necessary for the full …
/ROCK and p38 MAPK pathways as necessary for TGF-β-mediated growth inhibition, but …

MALT1 inhibition of oral carcinoma cell invasion and ERK/MAPK activation

T Chiba, Y Soeno, Y Shirako, H Sudo… - Journal of Dental …, 2016 - journals.sagepub.com
… These suggest that loss of MALT1 expression facilitates the carcinoma invasion. In the present
study, we examined a role of MALT1 in oral carcinoma cell invasion by in vitro assays and …