… One approach to enhance NMDA receptor function is to increase the … agonist glycine at this
modulatory site through inhibition of glycine reuptake from the synapse via glycine transporter…

… with the promising approach for enhancing NMDAR … glycine transporter 1 by glycine reuptake
inhibitors [76,77]. Furthermore, while this may be particularly important for the treatment of …

… In summary, glutamatergic approaches for treatment of schizophrenia were first proposed
more than 20 years ago. Nevertheless, compounds for testing these theories are only now …

… of synaptic glycine could prove effective in the treatment of … glycine levels, through
blockade of the glycine transporter-1 (… a rational approach for the treatment of schizophrenia. …

… enthusiasm for GlyT-1 inhibition as an approach to treat the disease. However, research in
the area remains quite active, as therapeutic potential for several additional indications has …

… ways to glutamate and glycine and also various endogenous modulators and pharmacological
agents. In addition, there is also enormous scope for developmental changes in the …

… More recently, preclinical studies have emerged that indicate the approach … inhibition and
describes drug discovery and development efforts toward the identification of novel inhibitors…

… as a therapeutic approach for the treatment of … inhibition deficits of the startle reflex in
neonatal ventral hippocampallesioned rats: reversal by glycine and a glycine transporter inhibitor. …

… PCP psychosis, in turn, forms the basis for an alternative theory of schizophrenia that is
only now leading to novel therapeutic approaches. PCP induces its unique psychotomimetic …

… inhibition of GlyR responses, and tropisetron, in spinal neurons, potentiates the effects of
low concentrations of glycine but inhibits glycine-mediated currents at higher concentrations. …