Characterization of anticancer agents by their growth inhibitory activity and relationships to mechanism of action and structure
… between (i) the growth inhibitory activities for a set of anticancer agents from the panel of
60 … of the tested agents; and (iii) their apparent mechanism of growth inhibitory action (MOA). …
60 … of the tested agents; and (iii) their apparent mechanism of growth inhibitory action (MOA). …
Plants as a source of anti-cancer agents
GM Cragg, DJ Newman - Journal of ethnopharmacology, 2005 - Elsevier
… Despite intensive research aimed at discovering other classes of compounds demonstrating
topoisomerase I inhibitory activity, only a few novel chemotypes have been identified. These …
topoisomerase I inhibitory activity, only a few novel chemotypes have been identified. These …
Recent progress in the development of anticancer agents
S Eckhardt - Current medicinal chemistry-anti-cancer agents, 2002 - ingentaconnect.com
… Recently, several compounds have been demonstrated to display dual topoisomerase I
and II inhibitory activity. Among them TAS-103 deserves attention. This compound is a novel …
and II inhibitory activity. Among them TAS-103 deserves attention. This compound is a novel …
Inhibitors of histone deacetylase as new anticancer agents
M Jung - Current Medicinal Chemistry, 2001 - ingentaconnect.com
… Abstract: Inhibitors of histone deacetylase (HDAC) are an emerging class of anticancer agents.
They … The enantiomer of 6 has been synthesized but did not show inhibitory activity [46]. …
They … The enantiomer of 6 has been synthesized but did not show inhibitory activity [46]. …
Inhibitors of carbohydrate processing: A new class of anticancer agents.
PE Goss, MA Baker, JP Carver, JW Dennis - … research: an official journal of the …, 1995 - AACR
… for anticancer agents with novel mechanisms of action. Recently identified molecular targets
for new anticancer agents … Of the carbohydrate-processing inhibitors presently available, the …
for new anticancer agents … Of the carbohydrate-processing inhibitors presently available, the …
Epidermal growth factor receptor tyrosine kinase inhibitors as anticancer agents
F Ciardiello - Drugs, 2000 - Springer
… CGP 54211 and CGP 53353 (Novartis) are 2 dianilinophthalimides with ATP-competitive
tyrosine kinase inhibitory activity that are only relatively selective for EGFR, since they also …
tyrosine kinase inhibitory activity that are only relatively selective for EGFR, since they also …
Dual or multi-targeting inhibitors: The next generation anticancer agents
NM Raghavendra, D Pingili, S Kadasi, A Mettu… - European journal of …, 2018 - Elsevier
… caused by BCR-ABL mutations of imatinib, by discovering series of 9-arenethenyl purines
possessing a trans double bond; many of these compounds have the dual inhibitory activity on …
possessing a trans double bond; many of these compounds have the dual inhibitory activity on …
Clinical development of histone deacetylase inhibitors as anticancer agents
DC Drummond, CO Noble, DB Kirpotin… - Annu. Rev …, 2005 - annualreviews.org
… In general, these inhibitors have nanamolar HDAC inhibitory activity and can have either
irreversible (epoxyketone-based) or reversible mechanisms of action. The macrocyclic peptide …
irreversible (epoxyketone-based) or reversible mechanisms of action. The macrocyclic peptide …
Histone deacetylase inhibitors: understanding a new wave of anticancer agents
A Villar‐Garea, M Esteller - International journal of cancer, 2004 - Wiley Online Library
… Compounds with proven HDAC-inhibitory activity. (a) Scheme showing the general structure
of most of these substances. (b) Examples of chemicals included in the different HDAC …
of most of these substances. (b) Examples of chemicals included in the different HDAC …
The statins as anticancer agents
… anticancer agents based on preclinical evidence of their antiproliferative, proapoptotic,
anti-invasive, and radiosensitizing properties. Inhibition … demonstrated growth inhibitory activity in …
anti-invasive, and radiosensitizing properties. Inhibition … demonstrated growth inhibitory activity in …
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