Injectable hydrogel containing tauroursodeoxycholic acid for anti-neuroinflammatory therapy after spinal cord injury in rats

GH Han, SJ Kim, WK Ko, D Lee, JS Lee, H Nah… - Molecular …, 2020 - Springer
… -inflammatory effects of injectable hydrogel containing tauroursodeoxycholic acid (TUDCA)
in … Hence, we hypothesized that a direct injection of the TUDCA-hydrogel (TC gel) can inhibit …

Injectable polypeptide thermogel as a tissue engineering system for hepatogenic differentiation of tonsil-derived mesenchymal stem cells

JH Hong, HJ Lee, B Jeong - ACS Applied Materials & Interfaces, 2017 - ACS Publications
hydrogel incorporating tonsil-derived mesenchymal stem cells (TMSCs), tauroursodeoxycholic
acid (TUDCA… aqueous polymer solution for an injectable tissue engineering application. …

[HTML][HTML] Injectable hydrogels for spinal cord injury repair

H Wang, H Zhang, Z Xie, K Chen, M Ma, Y Huang… - Engineered …, 2022 - Elsevier
hydrogels. After that, we focus on the in vivo therapeutic strategies and effects of injectable
hydrogels… Han et al. presented an injectable hydrogel loaded with tauroursodeoxycholic acid (…

Restoration of articular osteochondral defects in rat by a bi-layered hyaluronic acid hydrogel plug with TUDCA-PLGA microsphere

BJ Kim, Y Arai, B Choi, S Park, J Ahn, IB Han… - Journal of industrial and …, 2018 - Elsevier
Tauroursodeoxycholic acid (TUDCA) has a role in the regulation of the differentiation of
mesenchymal stem cells. In this study, TUDCA … that multiple injections of TUDCA improve bone …

Administration of tauroursodeoxycholic acid enhances osteogenic differentiation of bone marrow-derived mesenchymal stem cells and bone regeneration

BH Cha, MJ Jung, BK Moon, JS Kim, Y Ma, Y Arai… - Bone, 2016 - Elsevier
TUDCA-treated (multiple injections) and BMP-2-treated (1 or 3 μg) groups. By contrast, a
single TUDCA injection … higher in the TUDCA-treated group (multiple injections) than in the no …

The emerging role of bile acids as critical components in nanotechnology and bioengineering: Pharmacology, formulation optimizers and hydrogel-biomaterial …

B Kovacevic, M Jones, C Ionescu, D Walker, S Wagle… - Biomaterials, 2022 - Elsevier
… An alternative to surgery is the utilization of injectable cell delivery systems. However, this
… of this review would be on the role of bile acids (BAs) as possible excipient enhancer within …

Direct injection of hydrogels embedding gold nanoparticles for local therapy after spinal cord injury

WK Ko, SJ Lee, SJ Kim, GH Han, I Han… - …, 2021 - ACS Publications
… In this study, we created a hydrogel composed of glycol chitosan (gC) and oxidized
hyaluronate (oHA). Gold nanoparticles (GNPs) were conjugated with ursodeoxycholic …

[HTML][HTML] Controlled delivery of tauroursodeoxycholic acid from biodegradable microspheres slows retinal degeneration and vision loss in P23H rats

L Fernandez-Sanchez, I Bravo-Osuna, P Lax… - PLoS …, 2017 - journals.plos.org
… Homozygous P23H line 3 rats received a treatment of intravitreal injections of TUDCA-PLGA
MSs. Retinal function was assessed by electroretinography at P30, P60, P90 and P120. …

The role of tauroursodeoxycholic acid on adipogenesis of human adipose-derived stem cells by modulation of ER stress

BH Cha, JS Kim, JC Ahn, HC Kim, BS Kim, DK Han… - Biomaterials, 2014 - Elsevier
… The chemical chaperone tauroursodeoxycholic acid (TUDCA) not … In this study, we examine
whether TUDCA has an effect on … At five weeks after the injections, the grafts were explanted, …

Coaxially fabricated polylactic acid electrospun nanofibrous scaffold for sequential release of tauroursodeoxycholic acid and bone morphogenic protein2 to stimulate …

DP Bhattarai, MH Kim, H Park, WH Park, BS Kim… - Chemical Engineering …, 2020 - Elsevier
… Although, in this study, we used the TUDCA as an angiogenic factor, TUDCA has an
osteogenic potential too. According to the previous reports, direct local injections of TUDCA