Influence of parenteral administration routes and additional factors on vaccine safety and immunogenicity: a review of recent literature

C Herzog - Expert review of vaccines, 2014 - Taylor & Francis
… For parenteral vaccine administration there are currently three routes licensed: … or needle-free
injection devices. The factors potentially impacting on the ‘performance’ of a given route of …

Perspectives on subcutaneous route of administration as an immunogenicity risk factor for therapeutic proteins

L Hamuro, G Kijanka, F Kinderman… - Journal of …, 2017 - Elsevier
… Delaying drug absorption at the injection site can reduce dosing frequency, but also has
the potential to increase irritation at the injection site that could alter the immunogenicity risk …

Effect of vaccine administration modality on immunogenicity and efficacy

L Zhang, W Wang, S Wang - Expert review of vaccines, 2015 - Taylor & Francis
… influence on vaccine immunogenicity and efficacy: vaccination strategy, route of vaccine …
Several studies have shown that the immunogenicity of a vaccine is lower after IM injection

Immunogenicity and safety of different injection routes and schedules of IC41, a Hepatitis C virus (HCV) peptide vaccine

C Firbas, T Boehm, V Buerger, E Schuller, N Sabarth… - Vaccine, 2010 - Elsevier
… I study for dose and injection route optimization and further assessment of the safety of the
HCV peptide … The different injection schedules, volume of injection (vaccine dosage) and …

Immunogenicity and safety of a new inactivated hepatitis A vaccine: a clinical trial with comparison of administration route

A Fisch, P Cadilhac, E Vidor, T Prazuck, A Dublanchet… - Vaccine, 1996 - Elsevier
… In order to document the immunogenicity and the safety of the vaccine when injected by
other routes, we conducted a phase II study in order to compare the immunogenicity and …

Immunogenicity and safety of intradermal influenza vaccination in healthy older adults

RC Chi, MT Rock, KM Neuzil - Clinical infectious diseases, 2010 - academic.oup.com
… Of these subjects, 1 subject who was assigned to 0.3-mL ID injection was excluded …
injection route. Five subjects were excluded from the 4-week postvaccination immunogenicity

Anthrax vaccine: immunogenicity and safety of a dose-reduction, route-change comparison study in humans

PR Pittman, G Kim-Ahn, DY Pifat, K Coonan, P Gibbs… - Vaccine, 2002 - Elsevier
… Based upon passively collected data, we have known since the mid-1990s that the rate of
SQ injection site reactions was higher among women compared to men [16]. AVA is the only …

Clinical studies assessing immunogenicity and safety of intradermally administered influenza vaccines

V Vankerckhoven, P Van Damme - Expert opinion on drug delivery, 2010 - Taylor & Francis
… alternative route to increase the immunogenicityimmunogenic and safety profiles to im
vaccination. Local reactions were more frequently reported after id vaccination, whereas injection

[HTML][HTML] Immunogenicity and safety of concomitant administration of a measles, mumps and rubella vaccine (MM-RvaxPro®) and a varicella vaccine (VARIVAX®) by …

Y Gillet, P Habermehl, S Thomas, C Eymin, A Fiquet - BMC medicine, 2009 - Springer
… to compare the immunogenicity and safety of MM-RvaxPro and VARIVAX when both are
administered concomitantly at separate injection sites by either the SC or the IM route. …

[HTML][HTML] A phase 1, open-label, randomized study to compare the immunogenicity and safety of different administration routes and doses of virosomal influenza …

Y Levin, E Kochba, G Shukarev, S Rusch… - Vaccine, 2016 - Elsevier
… , which is thought to enhance the immunogenicity of influenza vaccines. There appeared
to be no correlation between injection volume or injection dose and incidence or severity of …