The ovarian cancer tumor immune microenvironment (TIME) as target for therapy: a focus on innate immunity cells as therapeutic effectors

D Baci, A Bosi, M Gallazzi, M Rizzi, DM Noonan… - International journal of …, 2020 - mdpi.com
innate and adaptive immunity in orchestrating tumor cell fate. Indeed, cancer immunotherapy
… , assuring the (re)activation of the host defenses, a major strategic role in fighting cancers. …

Interactions between innate and adaptive lymphocytes

G Gasteiger, AY Rudensky - Nature Reviews Immunology, 2014 - nature.com
innate lymphocyteinnate lymphocytes, and propose a model in which T cells of the adaptive
immune system function as antigen-specific sensors for the activation of innate lymphocytes

Approaches of the innate immune system to ameliorate adaptive immunotherapy for B-cell non-hodgkin lymphoma in their microenvironment

T Watanabe - Cancers, 2021 - mdpi.com
… However, the role of the innate immune system has been shown … for DLBCL, are novel innate
immune checkpoint inhibitors that … of approaches that trigger innate immune activation for …

The tumor microenvironment innately modulates cancer progression

DC Hinshaw, LA Shevde - Cancer research, 2019 - AACR
… understanding of the innate immune cells and extend … innate immune cells for cancer
promotion and clinical strategies targeting these innate immune responses in the context of cancer

Orchestrating an immune response against cancer with engineered immune cells expressing αβTCRs, CARs, and innate immune receptors: an immunological and …

MA de Witte, GJJ Kierkels, T Straetemans… - … , Immunotherapy, 2015 - Springer
… understanding of how innate immune cells can attack cancer cells without substantial side
… cells expressing innate immune receptors. Here, we focus on innate immune interventions …

Innate immune recognition and suppression of tumors

Y Hayakawa, MJ Smyth - Advances in cancer research, 2006 - Elsevier
… NK cells are specialized innate lymphocytes capable of distinguishing between normal
healthy cells and abnormal cells such as virus‐infected cells or transformed tumor cells (…

Phagocytosis checkpoints as new targets for cancer immunotherapy

M Feng, W Jiang, BYS Kim, CC Zhang, YX Fu… - … Reviews Cancer, 2019 - nature.com
… the use of phagocytosis checkpoint blockade in cancer treatment. We discuss the mechanistic
processes that govern innate and adaptive antitumour immune responses in the setting of …

Nucleic acid and oligonucleotide delivery for activating innate immunity in cancer immunotherapy

F Meng, J Wang, Y Yeo - Journal of Controlled Release, 2022 - Elsevier
… of the key components in vaccine development [9] and cancer immunotherapy [10]. However,
their … in cancer immunotherapy with a specific focus on the activation of the innate immune …

Emerging targets in cancer immunotherapy

S Burugu, AR Dancsok, TO Nielsen - Seminars in cancer biology, 2018 - Elsevier
lymphocytes associated with adaptive immunity − via blockade of immune-inhibitory checkpoints
or as agonists of immunostimulatory pathways − but also innate … hematopoietic cancers (…

Pharmacological targeting of natural killer cells for cancer immunotherapy

K Miyazato, Y Hayakawa - Cancer Science, 2020 - Wiley Online Library
… Natural killer (NK) cells are innate lymphocytes that rapidly respond to cancer cells without
prior sensitization or restriction to the cognate antigen in comparison with tumor antigen-…