… , obesity and insulin resistance. Although much attention has addressed early steps in the
insulin signaling cascade, insulin resistance in obesity … also connect insulin resistance to …

… of abnormal insulin or proinsulin molecules, the presence of circulating antagonists to
insulin or the insulin receptor, or defects in insulin action at … of obesity and of noninsulin-dependent …

… of normal insulin action. In this review, both the physiology of insulin action and the
pathophysiology of insulin resistance are described, focusing on three key insulin target tissues: …

… The initial molecular signal for insulin action involves activation of the insulin receptor tyrosine
kinase, which results in phosphorylation of insulin receptor substrates (IRSs) on multiple …

In obesity several mechanisms contribute to produce insulin resistance. Elevation of plasma
FFA increases the concentration of cytoplasmic long-chain-CoA (LC-CoA) and …

… The strong association between obesity (particularly central abdominal obesity) and impaired
insulin action, is the focus of this article, in which we discuss the insulin- signalling pathway…

… pathways controlling insulin action. This review aims at providing an overview of these
concepts and their potential inter-relationships in the development of insulin resistance, with …

… causally related to the development of the insulin resistance of obesity. On the basis of the
… defect in insulin action as the cause of the insulin resistance of obesity. Insulin action at the …

… , and contributes to the morbidity of obesity. Insulin action involves a series of signaling …
Furthermore, the role of Rho-kinase, a newly identified regulator of insulin action in insulin …

… to the situation in obese man, one could infer that a postreceptor defect in the insulin action-…
cause of insulin resistance, and that decreased cellular insulin receptors play a contributory …