… on the islet K ATP channel in the insulin secretion pathway, we used the K ATP channel …
did not suppress basal insulin secretion, and the stimulation of insulin secretion by addition of …

… glibenclamide, nateglinide or control insulin to diabetic GK (Goto-Kakizaki) rats for 6 weeks.
We then examined β-cell functions by TIRF imaging of insulin exocytosis, perifusion analysis …

… secrete sufficient insulin to compensate for the insulin resistance … because of insufficient
insulin secretion caused by genetic … by defects in both insulin action and insulin secretion ( 1,2 ). …

… in insulin secretion that we observed after EA in the present study was comparable with that
seen in earlier studies. Basal insulin secretion … EA accelerated insulin secretion even under …

… Insulin binds cell surface receptors in the liver, skeletal … the insulin response can trigger the
release of additional insulin from pancreatic β cells, followed by dysfunctional insulin release …

… in the first and second phases, but had little effect on insulin secretion at 2.8 mM glucose. In
… insulin secretion at 2.8 mM glucose and enhanced the second phase of insulin secretion but …

… On the other hand, as in the adult GK rat, islet insulin release in response to a nonfuel … in
islet insulin content. On the basis of these facts, we chronically administered insulin to young GK …

… We previously reported that the GotoKakizaki (GK) rat, an animal model of type 2 diabetes,
has hepatic insulin resistance using a perfused rat liver model. Pioglitazone, …

… of glucose-stimulated insulin release is a critical factor in the … islets of the spontaneously
diabetic GotoKakizaki (GK) rat … secretion coupling impairs insulin secretion in Goto-Kakizaki …

… a major cause of insufficient insulin secretion in response to high blood … Among these
models, Goto-Kakizaki (GK) rats have been … thickening in the Goto Kakizaki model of non-insulin- …